CHRDL1
CHRDL1 (chordin like 1, also known as NRLN1, CHL and MGC1) is a secreted member of the chordin family that antagonises bone morphogenetic protein 4 (BMP4). It binds BMP4 and prevents its interaction with receptors, influencing neural, skeletal and eye development. Browse Assay Genie's current range of CHRDL1 research reagents below, or read on for the biology behind the target.
The CHRDL1 protein, also called chordin-like protein 1, acts as an extracellular antagonist of BMP4. It binds BMP4 and prevents the growth factor from engaging its receptors, which dampens BMP4 signalling in the tissues where CHRDL1 is present. This mechanism underlies the roles assigned to it in development and in the nervous system.
In neural stem cells, CHRDL1 alters fate commitment from gliogenesis to neurogenesis. It contributes to neuronal differentiation in the brain by preventing the adoption of a glial fate. UniProt also notes that it may play a crucial role in dorsoventral axis formation and may play a role in embryonic bone formation. In the eye, CHRDL1 has a role during anterior segment development. It may also help regulate retinal angiogenesis by modulating BMP4 actions in endothelial cells. NCBI Gene adds that the protein may contribute to topographic retinotectal projection and to the regulation of retinal angiogenesis in response to hypoxia.
The CHRDL1 gene belongs to the chordin family and is located on the X chromosome. Alternatively spliced transcript variants encoding different isoforms have been described. The gene has also been known as NRLN1, CHL and MGC1, and its previous HGNC name was megalocornea 1 (X-linked). Mouse and rat orthologs are both designated Chrdl1, which allows the biology to be studied in common model organisms.
CHRDL1 binds BMP4 and blocks receptor interaction, making it a useful point of study for extracellular control of BMP activity.
CHRDL1 shifts neural stem cells from gliogenesis towards neurogenesis, supporting work on neuronal differentiation and glial fate.
CHRDL1 functions in anterior segment development and may regulate retinal angiogenesis through BMP4 action in endothelial cells.
CHRDL1 may contribute to dorsoventral axis formation and embryonic bone formation, linking BMP antagonism to early development.
CHRDL1 is a secreted antagonist of BMP4. By binding BMP4 it prevents the growth factor interacting with its receptors. This supports neuronal differentiation of neural stem cells, anterior segment eye development, and possibly retinal angiogenesis and embryonic bone formation.
CHRDL1 stands for chordin like 1, and UniProt lists it as chordin-like protein 1. Aliases include NRLN1, CHL and MGC1. Its previous HGNC name was megalocornea 1 (X-linked). NCBI Gene notes that alternatively spliced transcript variants encode different isoforms.
Yes. Orthologs of the human CHRDL1 gene exist in both mouse and rat, and both are named Chrdl1. This lets researchers study its BMP4-antagonist functions in rodent models; check the datasheet of any product for its validated reactivity.
Other chordin family members, BMP ligands and BMP antagonists relevant to CHRDL1 signalling biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BU40; product specifications from Assay Genie datasheets.