PLA2G1B
PLA2G1B (phospholipase A2 group IB) is a secreted, calcium-dependent phospholipase A2 produced by pancreatic acinar cells, where it acts mainly on dietary phospholipids in the intestinal tract. It is also known as PLA2, PPLA2 and PLA2A. Browse Assay Genie's current range of PLA2G1B research reagents below, or read on for the biology behind the target.
PLA2G1B is a secretory calcium-dependent phospholipase A2. It hydrolyses the ester bond of the fatty acyl group at the sn-2 position of phospholipids, with a preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. Hydrolysis of membrane glycerophospholipids releases arachidonic acid and lysophospholipids. Arachidonic acid is then converted by downstream enzymes into eicosanoids, including prostaglandins and leukotrienes, which are bioactive lipid mediators.
In the intestinal tract, the enzyme primarily targets dietary phospholipids. It may also contribute to the biosynthesis of N-acyl ethanolamines, which regulate energy metabolism and inflammation: it hydrolyses N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which a lysophospholipase D then cleaves to release N-acyl ethanolamines. PLA2G1B may act in an autocrine and paracrine manner, and it has been linked to cell contraction, cell proliferation and pathological responses.
Binding to the PLA2R1 receptor lets PLA2G1B regulate podocyte survival and glomerular homeostasis. The enzyme also has anti-helminth activity that is regulated by gut microbiota. During helminth infection of intestinal epithelia, it alters the phosphatidylethanolamine content of larval membranes. This is likely to affect phospholipid-mediated processes such as membrane fusion and cell division, and to improve immune recognition, reducing larval integrity and infectivity. The PLA2G1B gene belongs to the phospholipase A2 family and the HGNC phospholipases group. Its former name was phospholipase A2, group IB (pancreas). Mouse and rat both carry a Pla2g1b ortholog.
PLA2G1B releases arachidonic acid from membrane glycerophospholipids, the first step towards prostaglandins and leukotrienes.
The enzyme digests dietary phospholipids and may contribute to N-acyl ethanolamine biosynthesis, which regulates energy metabolism and inflammation in the gut.
PLA2G1B shows anti-helminth activity regulated by gut microbiota, altering phosphatidylethanolamine in larval membranes and reducing infectivity.
Binding to PLA2R1 allows PLA2G1B to regulate podocyte survival and glomerular homeostasis.
PLA2G1B is a secreted, calcium-dependent phospholipase A2 that cleaves the fatty acyl group at the sn-2 position of phospholipids, preferring phosphatidylethanolamines and phosphatidylglycerols. This releases arachidonic acid and lysophospholipids. In the gut it mainly acts on dietary phospholipids.
The official name is phospholipase A2 group IB, and the UniProt protein name is phospholipase A2. Aliases and previous symbols include PLA2, PPLA2 and PLA2A. The earlier gene name was phospholipase A2, group IB (pancreas), reflecting its production by pancreatic acinar cells.
Yes, orthologs named Pla2g1b exist in both mouse and rat. Functionally, human PLA2G1B has been linked to intestinal lipid handling, anti-helminth activity and, through the PLA2R1 receptor, podocyte survival. Check the datasheet of any product for its validated reactivity.
Other secreted and cytosolic phospholipase A2 enzymes, the PLA2R1 receptor and related lipid-metabolism targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P04054; product specifications from Assay Genie datasheets.