LAD1
LAD1 (ladinin 1) is an anchoring filament protein that forms part of the basement membrane zone. It is thought to help stabilise the association between epithelial layers and the underlying mesenchyme, and it is catalogued by UniProt as Ladinin-1. Browse Assay Genie's current range of LAD1 research reagents below, or read on for the biology behind the target.
LAD1, short for ladinin 1, is an anchoring filament protein and a component of the basement membrane zone. According to the RefSeq summary, the protein encoded by the LAD1 gene may be an anchoring filament within basement membranes, and it may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme. In other words, LAD1 is linked to the structural connection between an epithelium and the tissue beneath it, rather than to an enzymatic or signalling role.
UniProt records the LAD1 protein (Ladinin-1) as a secreted protein found in the extracellular space, where it is assigned to the extracellular matrix and, more specifically, the basement membrane. This localisation fits its description as an anchoring filament component. The LAD1 gene is identified by HGNC as ladinin 1, and no alternative gene symbols or previous names are listed for it. In mouse, the corresponding gene is Lad1.
Because the available annotation is concise, the functional wording is cautious: the protein is described as one that may be an anchoring filament and may contribute to epithelial-mesenchymal stability. Researchers studying basement membrane organisation, epithelial attachment or extracellular matrix composition will find LAD1 relevant as a defined member of the basement membrane zone. Work with the LAD1 protein, whether through an LAD1 antibody or an LAD1 ELISA kit, is typically aimed at understanding where and how this component contributes to the architecture of the epithelial-mesenchymal interface.
LAD1 is a component of the basement membrane zone, making it a relevant protein for studying how this specialised matrix is assembled.
LAD1 may contribute to the stability of the association between epithelial layers and the underlying mesenchyme.
LAD1 is described as an anchoring filament protein, so it is studied in work on structures that tether epithelia to the matrix.
UniProt places LAD1 in the secreted extracellular space, within the extracellular matrix and basement membrane.
LAD1 is an anchoring filament protein and a component of the basement membrane zone. The RefSeq summary suggests it may contribute to the stability of the association of epithelial layers with the underlying mesenchyme, though its role is described in cautious terms.
The HGNC full name is ladinin 1, and UniProt names the protein Ladinin-1. No aliases or previous gene symbols are listed. Searches for the LAD1 gene, LAD1 protein or ladinin 1 therefore refer to the same target.
A mouse ortholog, Lad1, is recorded for the human LAD1 gene. A rat ortholog is not given in the data used here. Check the datasheet of any product for its validated reactivity.
Other basement membrane, anchoring filament and extracellular matrix proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O00515; product specifications from Assay Genie datasheets.