SECTM1
SECTM1 (secreted and transmembrane 1, also known as K12) is a protein that exists in both a membrane-bound and a secreted form. It is thought to be involved in thymocyte signalling and in haematopoietic and immune system processes. Browse Assay Genie's current range of SECTM1 research reagents below, or read on for the biology behind the target.
SECTM1 is a protein that is found at the cell membrane and also released into the extracellular space. UniProt annotates its function cautiously: it may be involved in thymocyte signalling. The NCBI Gene summary similarly describes it as thought to be involved in haematopoietic and/or immune system processes. Its precise molecular mechanism is not defined in the sources used for this page.
The SECTM1 gene encodes a transmembrane and secreted protein with the characteristics of a type 1a transmembrane protein. Within the cell, it has been found in a perinuclear, Golgi-like pattern, which fits a protein that moves through the secretory pathway to reach the cell surface or be released. SECTM1 belongs to the SECTM family.
The gene is also known by the alias K12, and the official name, secreted and transmembrane 1, reflects its dual localisation. In mouse, the corresponding ortholog is named Sectm1b. Researchers studying SECTM1 typically do so in the context of immune cell biology and haematopoietic development, where its proposed roles lie. Because the functional annotation is limited, work on the SECTM1 protein often focuses on defining where it is expressed, how it is processed between membrane-bound and secreted forms, and what signalling role it plays in thymocytes.
SECTM1 may be involved in thymocyte signalling, making it a candidate for studies of T-cell development in the thymus.
The gene is thought to contribute to immune system processes, so SECTM1 is relevant to research on immune cell function.
NCBI Gene describes a proposed role in haematopoietic processes, motivating investigation of SECTM1 in blood cell lineages.
SECTM1 shows a perinuclear Golgi-like pattern and exists as membrane-bound and secreted forms, which suits studies of protein trafficking.
The function of SECTM1 is not fully defined. UniProt states that it may be involved in thymocyte signalling, and NCBI Gene describes it as thought to be involved in haematopoietic and/or immune system processes. It is both a cell membrane and a secreted protein.
SECTM1 stands for secreted and transmembrane 1, and the gene has the alias K12. It encodes a protein with characteristics of a type 1a transmembrane protein and belongs to the SECTM family. It is found at the cell membrane and in secreted form.
The mouse has a corresponding ortholog named Sectm1b, which allows comparative work in mouse models. No rat ortholog is given in the data used here. Check the datasheet of any product for its validated reactivity.
Other immune signalling proteins, thymocyte markers and secreted or transmembrane targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8WVN6; product specifications from Assay Genie datasheets.