DBP
DBP (D-box binding PAR bZIP transcription factor, also known as DABP or D site-binding protein) is a nuclear transcriptional activator of the PAR bZIP family. It binds defined promoter sequences and modulates circadian clock output genes. Browse Assay Genie's current range of DBP research reagents below, or read on for the biology behind the target.
DBP is a transcriptional activator that recognises and binds the DNA sequence 5'-RTTAYGTAAY-3', found in the promoters of genes such as albumin, CYP2A4 and CYP2A5. The DBP protein can bind DNA as a homodimer or as a heterodimer. Its transactivation activity is enhanced when it forms a heterodimer with HLF, and in this form it activates transcription of the coagulation factors F8 and F9.
DBP is not essential for generating circadian rhythms, but it modulates important clock output genes. It may be a direct target for regulation by the circadian pacemaker component clock, and it may affect circadian period and sleep regulation. The DBP gene encodes a member of the PAR bZIP transcription factor family, and UniProt classifies the protein in the PAR subfamily of the bZIP family. The protein is localised to the nucleus, consistent with its role in controlling gene expression.
The name reflects its original identification as a factor binding the D site of the albumin promoter, also called the albumin D-box, which gave rise to the alias DABP. In mouse the ortholog is Dbp. Researchers studying DBP often place it within work on circadian output, liver-expressed promoters and the transcriptional control of coagulation factor genes.
DBP modulates important clock output genes and may be a direct target of the circadian pacemaker component clock.
DBP may affect circadian period and sleep regulation, making it relevant to studies of timing and behaviour.
DBP binds the sequence 5'-RTTAYGTAAY-3' in promoters such as albumin, CYP2A4 and CYP2A5, as a homodimer or heterodimer.
DBP activates transcription of F8 and F9, with activity enhanced by heterodimer formation with HLF.
DBP is a nuclear transcriptional activator that binds the sequence 5'-RTTAYGTAAY-3' in promoters such as albumin, CYP2A4 and CYP2A5. It modulates circadian clock output genes and activates F8 and F9 transcription, with enhanced activity as a heterodimer with HLF.
DBP is the official symbol for D-box binding PAR bZIP transcription factor. UniProt lists it as D site-binding protein, DABP is a previous symbol, and an earlier name was D site of albumin promoter (albumin D-box) binding protein.
A mouse ortholog, Dbp, is recorded for this gene. DBP is not essential for circadian rhythm generation, but it modulates clock output genes and may affect circadian period and sleep regulation. Check the datasheet of any product for its validated reactivity.
Partner transcription factors, circadian clock components and target genes linked to DBP function.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q10586; product specifications from Assay Genie datasheets.