CLGN
CLGN (calmegin) is a testis-specific chaperone of the endoplasmic reticulum that belongs to the calreticulin family. It acts during spermatogenesis and is required for normal male fertility. Browse Assay Genie's current range of CLGN research reagents below, or read on for the biology behind the target.
CLGN encodes calmegin, a chaperone that functions during spermatogenesis. It acts on a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for the subsequent penetration of the zona pellucida. Calmegin is also required for normal sperm migration from the uterus into the oviduct, and for normal male fertility. The protein binds calcium ions, a property shared with other members of its family.
Calmegin is a testis-specific protein that sits in the endoplasmic reticulum membrane. It belongs to the calreticulin family, and HGNC places the gene in the calnexin/calreticulin family group. The human CLGN gene has a mouse ortholog, Clgn, which allows the function of the protein to be studied in a model organism.
RefSeq describes CLGN as a gene that may play a role in spermatogenesis and infertility. Researchers studying sperm-egg interaction, protein folding in the male germ line and the molecular basis of male infertility therefore use calmegin as a target. Reagents for CLGN, including any CLGN antibody or protein, support work on where and when this chaperone is expressed and how it supports its client proteins.
Calmegin works as a chaperone during spermatogenesis, making CLGN a useful target for studying how germ cells fold and handle client proteins.
CLGN is required for normal male fertility and may play a role in infertility, which makes it relevant to investigating its genetic and molecular causes.
Calmegin supports client proteins involved in sperm adhesion to the zona pellucida and in zona penetration, so it is studied in fertilisation biology.
As a calcium-binding calreticulin family member in the endoplasmic reticulum membrane, calmegin is a model for tissue-restricted chaperone function.
CLGN encodes calmegin, an endoplasmic reticulum chaperone that acts during spermatogenesis. Its client proteins are important for sperm adhesion to the egg zona pellucida and for zona penetration. It is also required for sperm migration from the uterus into the oviduct and for normal male fertility.
Yes. UniProt places calmegin in the calreticulin family, and HGNC lists CLGN in the calnexin/calreticulin family gene group. Like other family members it binds calcium ions, but calmegin is testis-specific, whereas this page's source data describe it as acting in spermatogenesis.
Yes, the mouse ortholog is Clgn. This allows the role of calmegin in spermatogenesis and fertility to be investigated in a mouse model. Please check the datasheet of any product for its validated reactivity.
Other calreticulin family chaperones and endoplasmic reticulum proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O14967; product specifications from Assay Genie datasheets.