CRISP3
CRISP3 (cysteine rich secretory protein 3, also known as SGP28, CRISP-3, CRS3 and Aeg2) is a secreted member of the CRISP family. It is expressed in the male and female reproductive tracts, where it contributes to sperm function, fertilisation and endometrial receptivity. Browse Assay Genie's current range of CRISP3 research reagents below, or read on for the biology behind the target.
CRISP3 is a member of the cysteine-rich secretory protein (CRISP) family, which sits within the wider CRISP, antigen 5 and pathogenesis-related superfamily. The encoded protein has an N-terminal domain of the CRISP, antigen 5 and pathogenesis-related type, a hinge region, and a C-terminal ion channel regulator domain. Cysteine residues in both the N- and C-terminal domains form eight disulfide bonds, a distinguishing characteristic of the family. The mature CRISP3 protein is secreted.
The CRISP3 gene is expressed in the male reproductive tract, where the protein plays a role in sperm function and fertilisation. It is also expressed in the female reproductive tract, where it has a role in endometrial receptivity for embryo implantation. This dual presence makes CRISP3 a useful subject for studies of reproductive biology. Alternative splicing of the gene results in multiple transcript variants, which is worth bearing in mind when designing expression studies. The mouse ortholog is Crisp3, which allows comparative work in a widely used model organism.
CRISP3 is also of interest in cancer research, because the gene is upregulated in certain types of prostate cancer. Beyond the approved symbol, the gene and protein appear in the literature under several aliases, including SGP28, CRISP-3, CRS3, dJ442L6.3 and Aeg2. HGNC places CRISP3 in the cysteine rich secretory protein family, alongside related members such as CRISP2, so it is helpful to check which family member a study actually addresses when comparing results across publications.
CRISP3 is expressed in the male reproductive tract, where it plays a role in sperm function and fertilisation.
In the female reproductive tract, CRISP3 plays a role in endometrial receptivity for embryo implantation.
The CRISP3 gene is upregulated in certain types of prostate cancer, making it a point of interest in tumour studies.
Its CRISP domain, hinge and ion channel regulator domain, stabilised by eight disulfide bonds, typify the family's architecture.
CRISP3 is a secreted protein expressed in the male reproductive tract, where it plays a role in sperm function and fertilisation. It is also expressed in the female reproductive tract, where it contributes to endometrial receptivity for embryo implantation.
CRISP3 is also called SGP28, CRISP-3, CRS3, dJ442L6.3 and Aeg2. The full name is cysteine rich secretory protein 3. Alternative splicing of the gene produces multiple transcript variants, so it is worth confirming which variants a given reagent can detect.
The CRISP3 gene is upregulated in certain types of prostate cancer. A mouse ortholog, Crisp3, exists. Check the datasheet of any product for its validated reactivity before using it in a particular species.
Other members of the cysteine-rich secretory protein family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P54108; product specifications from Assay Genie datasheets.