TEAD4
TEAD4 (TEA domain transcription factor 4, also known as TEF-3, TEFR-1, EFTR-2, RTEF-1 and TCF13L1) is a nuclear transcription factor of the TEA/ATTS family. It acts in the Hippo signalling pathway and directs gene expression linked to proliferation and migration. Browse Assay Genie's current range of TEAD4 research reagents below, or read on for the biology behind the target.
TEAD4 is a transcription factor that plays a key role in the Hippo signalling pathway, which controls organ size and acts in tumour suppression by restricting proliferation and promoting apoptosis. The core of the pathway is a kinase cascade in which MST1/MST2, in complex with SAV1, phosphorylates and activates LATS1/2 in complex with MOB1. LATS1/2 in turn phosphorylates and inactivates the YAP1 oncoprotein and WWTR1/TAZ. TEAD4 acts by mediating the gene expression programmes of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and induction of epithelial mesenchymal transition (EMT).
At the DNA level, the TEAD4 protein binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. It also binds the M-CAT motif. The TEAD4 gene encodes a member of the transcriptional enhancer factor (TEF) family, defined by the TEA/ATTS DNA-binding domain. According to the NCBI Gene summary, it is preferentially expressed in skeletal muscle, where binding to the M-CAT regulatory element in promoters of muscle-specific genes directs their expression. Alternatively spliced transcripts encode distinct isoforms, and some are translated from a non-AUG (UUG) initiation codon.
TEAD4 belongs to the HGNC group of TEA domain transcription factors. Its previous name was TEA domain family member 4, and the UniProt protein name is transcriptional enhancer factor TEF-3. A mouse ortholog, Tead4, is recorded. Related family members include TEAD1 and TEAD3.
TEAD4 mediates the transcriptional output of YAP1 and WWTR1/TAZ, making it central to studies of the Hippo kinase cascade.
The Hippo pathway restricts proliferation and promotes apoptosis, and TEAD4 helps regulate these processes through gene expression.
TEAD4 contributes to regulation of cell migration and induction of epithelial mesenchymal transition, relevant to tumour biology research.
TEAD4 is preferentially expressed in skeletal muscle and binds M-CAT elements to direct expression of muscle-specific genes.
TEAD4 is a nuclear transcription factor in the Hippo signalling pathway. It mediates gene expression driven by YAP1 and WWTR1/TAZ, regulating cell proliferation, migration and EMT induction. It binds the Sph and GT-IIC enhansons and the M-CAT motif to activate transcription.
TEAD4 is also called TEF-3, TEFR-1, EFTR-2, RTEF-1 and TCF13L1, and was previously named TEA domain family member 4. NCBI describes alternatively spliced transcripts encoding distinct isoforms, some translated from a non-AUG (UUG) initiation codon.
A mouse ortholog, Tead4, is recorded for this gene. TEAD4 is one of the TEA domain transcription factors, which share the TEA/ATTS DNA-binding domain. Check the datasheet of any product for its validated reactivity.
Other TEA domain transcription factors that share the TEA/ATTS DNA-binding domain with TEAD4.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15561; product specifications from Assay Genie datasheets.