ESD
ESD (esterase D) is a serine hydrolase of the esterase D family, also known as S-formylglutathione hydrolase. It is involved in the detoxification of formaldehyde and is active toward a range of substrates, including O-acetylated sialic acids. Browse Assay Genie's current range of ESD research reagents below, or read on for the biology behind the target.
ESD is a serine hydrolase that contributes to the detoxification of formaldehyde. Its UniProt name, S-formylglutathione hydrolase, reflects its classification as a thioester hydrolase (EC 3.1.2.12). The enzyme is also active toward numerous other substrates, including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. Researchers studying formaldehyde metabolism or sialic acid turnover therefore often include the ESD protein in their work.
The ESD gene encodes a member of the esterase D family and belongs to the HGNC gene group of thioester hydrolases. In UniProt, the ESD protein is annotated as localised to the cytoplasm and to cytoplasmic vesicles. Mouse and rat carry orthologous genes, both named Esd, which allows comparative work in common model organisms.
The gene was previously named esterase D/formylglutathione hydrolase, a name that combines the two activities historically attached to it. ESD is used as a genetic marker for retinoblastoma and for Wilson's disease. This marker role is why ESD appears in genetics and disease-association research, as well as in studies of its enzymatic function. Any ESD antibody or ESD ELISA kit should be matched to the species and application of your experiment.
ESD is a serine hydrolase involved in the detoxification of formaldehyde, making it relevant to studies of aldehyde handling in cells.
The enzyme is active toward O-acetylated sialic acids and may be involved in sialic acid recycling.
ESD serves as a genetic marker for retinoblastoma and Wilson's disease, supporting linkage and disease-association research.
As an esterase D family member in the thioester hydrolase group, ESD is a reference point for comparative enzyme studies.
ESD is a serine hydrolase involved in the detoxification of formaldehyde. It is also active toward numerous substrates, including O-acetylated sialic acids, and may contribute to sialic acid recycling. UniProt places it in the cytoplasm and cytoplasmic vesicles.
ESD stands for esterase D. UniProt names the protein S-formylglutathione hydrolase, and the gene was previously called esterase D/formylglutathione hydrolase. No alternative gene symbols are listed. The enzyme carries the EC number 3.1.2.12.
Mouse and rat both have an orthologous gene named Esd. In humans, ESD is used as a genetic marker for retinoblastoma and Wilson's disease. Check the datasheet of any product for its validated reactivity.
Related enzymes and markers in formaldehyde and sialic acid metabolism may be listed here as pages become available.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P10768; product specifications from Assay Genie datasheets.