RTN4RL1
RTN4RL1 (reticulon 4 receptor like 1), also known as NGRH2 and NgR3, is a cell surface receptor of the Nogo receptor family. It contributes to brain development and restricts axon regeneration and synapse formation in the central nervous system. Browse Assay Genie's current range of RTN4RL1 research reagents below, or read on for the biology behind the target.
RTN4RL1 is a cell surface receptor that acts in neuronal development and in the response of the adult central nervous system to injury. It binds neuronal chondroitin sulfate proteoglycans and heparin, and through the proteoglycan interaction it inhibits neurite outgrowth and axon regeneration. Its signalling activates Rho, which leads to reorganisation of the actin cytoskeleton. The protein is reported to play a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system.
Beyond regeneration, RTN4RL1 contributes to normal axon migration across the brain midline and to normal formation of the corpus callosum. Like other members of its family, it restricts the number of dendritic spines and the number of synapses formed during brain development. It also protects motoneurons against apoptosis, and this protection is probably mediated by MAG. NCBI Gene describes it as enabling signalling receptor activity and predicts roles in negative regulation of axon regeneration and positive regulation of synapse assembly.
The RTN4RL1 gene belongs to the reticulon 4 receptor family in HGNC nomenclature, and the protein belongs to the Nogo receptor family. UniProt records its location at the cell membrane, including membrane rafts, as well as in the perikaryon and cell projections. The previous name, reticulon 4 receptor-like 1, and the aliases NGRH2, NgR3 and DKFZp547J144 all refer to the same gene. Mouse and rat both carry an ortholog named Rtn4rl1, which supports comparative neuroscience work on this receptor.
RTN4RL1 inhibits neurite outgrowth and axon regeneration through chondroitin sulfate proteoglycans, making it relevant to studies of repair in the adult central nervous system.
The receptor restricts dendritic spine number and synapse formation during brain development, which makes it a target for studies of synaptic connectivity.
RTN4RL1 contributes to axon migration across the brain midline and to normal formation of the corpus callosum.
Signalling through RTN4RL1 activates Rho and reorganises the actin cytoskeleton, providing a route to study receptor-driven cytoskeletal change in neurons.
RTN4RL1 is a cell surface receptor in the Nogo receptor family. It inhibits neurite outgrowth and axon regeneration by binding neuronal chondroitin sulfate proteoglycans, restricts dendritic spine and synapse numbers, and signals through Rho to reorganise the actin cytoskeleton. It also protects motoneurons against apoptosis.
RTN4RL1 is also called NGRH2 and NgR3, with DKFZp547J144 as a further alias. Its full name is reticulon 4 receptor like 1, and UniProt lists it as reticulon-4 receptor-like 1. Its older HGNC name was reticulon 4 receptor-like 1.
Yes. Both mouse and rat have an ortholog named Rtn4rl1, so the receptor can be studied in standard rodent models of brain development and axon regeneration. Check the datasheet of any product for its validated reactivity.
Other Nogo receptor family members and reticulon proteins relevant to axon regeneration and neuronal development research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q86UN2; product specifications from Assay Genie datasheets.