TEX101
TEX101 (testis expressed 101) is a membrane-associated protein that plays a role in fertilisation, controlling sperm binding to the zona pellucida and the migration of spermatozoa into the oviduct. It is also known as SGRG, CT131, SPATA44, TES101RP and MGC4766. Browse Assay Genie's current range of TEX101 research reagents below, or read on for the biology behind the target.
TEX101 plays a role in fertilisation by controlling the binding of sperm to the zona pellucida and the migration of spermatozoa into the oviduct. UniProt also notes that it may play a role in signal transduction and promote protein tyrosine phosphorylation. NCBI Gene describes the human gene as predicted to be involved in sperm binding to the zona pellucida, flagellated sperm motility and the regulation of that motility.
The protein is annotated at several subcellular sites: the cell membrane, membrane rafts, and the acrosome, a secretory vesicle of the sperm head. It is also listed as secreted and as present in cytoplasmic vesicles. NCBI Gene predicts it to be located in the acrosomal vesicle, the extracellular region and the plasma membrane, and to be active in plasma membrane rafts. These locations fit a role at the sperm surface during gamete interaction. The TEX101 gene belongs to the HGNC gene group LY6/PLAUR domain containing, and mouse and rat orthologs, both named Tex101, have been identified.
The gene has carried several names. Its previous HGNC name was testis expressed sequence 101, and aliases include MGC4766, SGRG, CT131, SPATA44 and TES101RP. Researchers studying the TEX101 protein typically work on male fertility, sperm function and the biology of the sperm membrane.
TEX101 controls sperm binding to the zona pellucida, making it a relevant protein for studying the molecular steps of fertilisation.
The protein is annotated as controlling the migration of spermatozoa into the oviduct, which is relevant to sperm transport research.
NCBI Gene predicts involvement in flagellated sperm motility and its regulation, which supports work on sperm function.
TEX101 is found in membrane rafts and may promote protein tyrosine phosphorylation, which is of interest in signal transduction studies.
TEX101 plays a role in fertilisation. According to UniProt, it controls the binding of sperm to the zona pellucida and the migration of spermatozoa into the oviduct. It may also play a role in signal transduction and promote protein tyrosine phosphorylation.
The HGNC name is testis expressed 101, and the UniProt name is Testis-expressed protein 101. Aliases and previous symbols include MGC4766, SGRG, CT131, SPATA44 and TES101RP. The previous HGNC name was testis expressed sequence 101.
Mouse and rat orthologs, both named Tex101, are recorded in the gene data. Human TEX101 belongs to the LY6/PLAUR domain containing gene group. Check the datasheet of any product for its validated reactivity.
Other sperm surface, zona pellucida and LY6/PLAUR domain proteins relevant to fertilisation research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BY14; product specifications from Assay Genie datasheets.