PFDN1
PFDN1 (prefoldin subunit 1, also known as PFD1) is a beta-type subunit of prefoldin, a molecular chaperone complex that binds newly synthesised polypeptides and passes them to cytosolic chaperonin to support correct folding. Browse Assay Genie's current range of PFDN1 research reagents below, or read on for the biology behind the target.
PFDN1 binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. It also binds to the nascent polypeptide chain and promotes folding in an environment where many competing pathways exist for nonnative proteins. In this way the PFDN1 protein acts as a handover step between protein synthesis and chaperonin-assisted folding.
PFDN1 is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilises newly synthesised polypeptides so that they can fold correctly. The complex contains two alpha and four beta subunits, and it forms a double beta barrel assembly with six protruding coiled-coils. PFDN1 belongs to the prefoldin subunit beta family, and the PFDN1 gene encodes a member of this beta subunit group. The mouse ortholog is Pfdn1.
The gene is listed by HGNC in the prefoldin subunits gene group. Its approved name is prefoldin subunit 1, its previous name was prefoldin 1, and PFD1 is a recognised alias. Other prefoldin subunits, such as PFDN2 and PFDN5, assemble with PFDN1 in the same complex, so studies of PFDN1 often consider the whole prefoldin assembly rather than a single subunit.
PFDN1 binds nascent polypeptide chains and promotes folding where many competing pathways exist for nonnative proteins.
PFDN1 binds cytosolic chaperonin and transfers target proteins to it, making it relevant to studies of chaperone handover.
PFDN1 is one of four beta subunits that, with two alpha subunits, form the prefoldin double beta barrel assembly.
As part of a chaperone complex that stabilises newly synthesised polypeptides, PFDN1 supports work on how cells maintain correct protein folding.
PFDN1 is a subunit of the prefoldin chaperone complex. It binds specifically to cytosolic chaperonin and transfers target proteins to it, and it binds nascent polypeptide chains to promote folding when many competing pathways exist for nonnative proteins.
The HGNC-approved name is prefoldin subunit 1. PFD1 is an alias, and prefoldin 1 is a previous name. UniProt lists the protein as prefoldin subunit 1 and places it in the prefoldin subunit beta family.
A mouse ortholog, Pfdn1, is recorded. PFDN1 is one of six prefoldin subunits: two alpha and four beta. Together they form a double beta barrel with six protruding coiled-coils. Check the datasheet of any product for its validated reactivity.
Other prefoldin subunits that assemble with PFDN1 in the chaperone complex.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O60925; product specifications from Assay Genie datasheets.