FBP1
FBP1 (fructose-1,6-bisphosphatase 1, also known as FBP) is a gluconeogenesis regulatory enzyme that hydrolyses fructose 1,6-bisphosphate to fructose 6-phosphate. It acts as a rate-limiting step in gluconeogenesis and belongs to the FBPase class 1 family. Browse Assay Genie's current range of FBP1 research reagents below, or read on for the biology behind the target.
FBP1 catalyses the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate in the presence of divalent cations. This reaction is a rate-limiting step in gluconeogenesis, the pathway that generates glucose from non-carbohydrate precursors, so FBP1 is regarded as a key regulatory enzyme of glucose production.
Beyond its core catalytic role, UniProt annotation describes several additional functions. FBP1 plays a role in regulating glucose sensing and insulin secretion in pancreatic beta-cells, and it appears to modulate glycerol gluconeogenesis in the liver. It is also described as an important regulator of appetite and adiposity: increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides, which seems to provide a feedback mechanism that limits weight gain.
The human FBP1 gene is a member of the HGNC group of fructose-1,6-bisphosphatases, and the protein belongs to the FBPase class 1 family. Mouse and rat each have an ortholog named Fbp1, which allows the enzyme to be studied in rodent models. Fructose-1,6-diphosphatase deficiency is associated with hypoglycaemia and metabolic acidosis, which links FBP1 directly to human metabolic disease. FBP2 is a related fructose-1,6-bisphosphatase gene.
FBP1 is a rate-limiting enzyme in gluconeogenesis, making it a central subject for studies of glucose production and its regulation.
FBP1 plays a role in glucose sensing and insulin secretion in pancreatic beta-cells, relevant to studies of islet function.
Hepatic FBP1 expression after nutrient excess is linked to satiety hormones and reduced appetite-stimulating neuropeptides, supporting feedback and weight-gain research.
Fructose-1,6-diphosphatase deficiency is associated with hypoglycaemia and metabolic acidosis, so FBP1 is relevant to inherited metabolic disorder research.
FBP1 catalyses the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate, a rate-limiting step in gluconeogenesis. It also contributes to glucose sensing and insulin secretion in pancreatic beta-cells, modulates glycerol gluconeogenesis in liver and helps regulate appetite and adiposity.
The approved HGNC name is fructose-bisphosphatase 1, and the previous name was fructose-1,6-bisphosphatase 1. The earlier symbol is FBP. UniProt lists the protein as fructose-1,6-bisphosphatase 1, with the enzyme classified as EC 3.1.3.11 in the FBPase class 1 family.
Yes, both mouse and rat have an ortholog named Fbp1. Fructose-1,6-diphosphatase deficiency is associated with hypoglycaemia and metabolic acidosis in humans. Check the datasheet of any product for its validated reactivity.
Other fructose-1,6-bisphosphatase family members and gluconeogenesis-related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P09467; product specifications from Assay Genie datasheets.