PTPRF
PTPRF (protein tyrosine phosphatase receptor type F), also known as LAR, is a receptor-type protein tyrosine phosphatase that spans the cell membrane. It regulates epithelial cell-cell contacts at adherens junctions and controls beta-catenin signalling. Browse Assay Genie's current range of PTPRF research reagents below, or read on for the biology behind the target.
PTPRF is a member of the protein tyrosine phosphatase (PTP) family, which belongs to the receptor class 2A subfamily. PTPs are signalling molecules that regulate cellular processes including cell growth, differentiation, the mitotic cycle and oncogenic transformation. PTPRF is a receptor-type PTP with an extracellular region, a single transmembrane region and two tandem intracytoplasmic catalytic domains. The first phosphatase domain carries the enzymatic activity, while the second appears to influence the substrate specificity of the first.
The extracellular region contains three Ig-like domains and nine non-Ig domains similar to those of neural-cell adhesion molecule. This architecture is reflected in its HGNC gene groups, which include fibronectin type III domain containing, I-set domain containing, protein tyrosine phosphatases receptor type, and the LAR protein receptor tyrosine phosphatase family. The PTPRF gene has mouse and rat orthologs, both named Ptprf. Two alternatively spliced transcript variants have been reported, and they encode distinct proteins.
Functionally, PTPRF has been shown to regulate epithelial cell-cell contacts at adherens junctions and to control beta-catenin signalling. Increased expression was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and it may contribute to the pathogenesis of insulin resistance. The symbol LAR is used as an alias in the literature, so researchers working on the PTPRF gene or protein will encounter both names.
PTPRF regulates epithelial cell-cell contacts at adherens junctions, making it relevant to studies of junction organisation and adhesion signalling.
PTPRF takes part in controlling beta-catenin signalling, so it is studied in work on pathways governing cell growth and differentiation.
Raised PTPRF expression in insulin-responsive tissue of obese, insulin-resistant individuals points to a role in the pathogenesis of insulin resistance.
As a receptor-type PTP with two catalytic domains, PTPRF is a model for how tyrosine phosphatases regulate growth, the mitotic cycle and transformation.
PTPRF is a receptor-type protein tyrosine phosphatase. Its first phosphatase domain is catalytically active, while the second appears to affect substrate specificity. It regulates epithelial cell-cell contacts at adherens junctions and controls beta-catenin signalling.
Yes. LAR is an alias of PTPRF, whose full name is protein tyrosine phosphatase receptor type F. UniProt names the protein receptor-type tyrosine-protein phosphatase F. Two alternatively spliced transcript variants have been reported, and they encode distinct proteins.
Mouse and rat both have a Ptprf ortholog; check the datasheet of any product for its validated reactivity. Increased PTPRF expression was found in insulin-responsive tissue of obese, insulin-resistant individuals and may contribute to insulin resistance.
Other receptor tyrosine phosphatases, adhesion molecules and beta-catenin and insulin signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P10586; product specifications from Assay Genie datasheets.