RAPSN
RAPSN (receptor associated protein of the synapse, also known as RNF205, CMS1D and CMS1E) is a postsynaptic protein required for clustering nicotinic acetylcholine receptors at the neuromuscular junction. It anchors the receptors to the underlying postsynaptic cytoskeleton. Browse Assay Genie's current range of RAPSN research reagents below, or read on for the biology behind the target.
RAPSN is a postsynaptic protein that is required for the clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It is thought to link the receptor to the underlying postsynaptic cytoskeleton, possibly through direct association with actin or spectrin. In this way it plays a critical role in clustering and anchoring nAChRs at synaptic sites. UniProt records its subcellular locations as the cell membrane, the postsynaptic cell membrane and the cytoskeleton within the cytoplasm.
The human RAPSN gene encodes a member of the RAPsyn family, a group of receptor associated proteins of the synapse. The encoded protein contains a conserved cAMP-dependent protein kinase phosphorylation site. Alternatively spliced transcript variants encoding multiple isoforms have been observed. The mouse ortholog is Rapsn. HGNC places the gene in the groups of ring finger proteins and RING finger E3 ubiquitin protein ligases, which is reflected in the alias RNF205.
The protein was originally named the 43 kDa receptor-associated protein of the synapse, and HGNC lists the previous name as receptor-associated protein of the synapse, 43kD. Mutations in the RAPSN gene may play a role in postsynaptic congenital myasthenic syndromes, which explains the aliases CMS1D and CMS1E. This makes RAPSN a useful subject for studies of synapse assembly and of neuromuscular transmission disorders.
RAPSN is required for clustering nicotinic acetylcholine receptors at the neuromuscular junction, so it is central to studies of postsynaptic organisation.
Mutations in the RAPSN gene may play a role in postsynaptic congenital myasthenic syndromes, making it relevant to disease research.
RAPSN may link receptors to the postsynaptic cytoskeleton, possibly by direct association with actin or spectrin.
RAPSN anchors nicotinic acetylcholine receptors at synaptic sites, offering a route to study how receptors are stabilised at the membrane.
RAPSN is a postsynaptic protein required for clustering nicotinic acetylcholine receptors at the neuromuscular junction. It may link the receptors to the postsynaptic cytoskeleton, possibly by direct association with actin or spectrin, thereby anchoring them at synaptic sites.
RAPSN is also called RNF205, CMS1D and CMS1E, and its UniProt name is 43 kDa receptor-associated protein of the synapse. An earlier HGNC name was receptor-associated protein of the synapse, 43kD. Multiple isoforms arise from alternatively spliced transcript variants.
Mutations in the RAPSN gene may play a role in postsynaptic congenital myasthenic syndromes, as noted in the NCBI Gene summary. A mouse ortholog, Rapsn, exists; check the datasheet of any product for its validated reactivity.
Other synaptic, neuromuscular junction and receptor-clustering targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13702; product specifications from Assay Genie datasheets.