NEUROG1
NEUROG1 (neurogenin 1) is a basic helix-loop-helix transcription factor that acts as a transcriptional regulator and is involved in the initiation of neuronal differentiation. It is also known as AKA, Math4C, ngn1, bHLHa6 and NEUROD3. Browse Assay Genie's current range of NEUROG1 research reagents below, or read on for the biology behind the target.
NEUROG1 acts as a transcriptional regulator and is involved in the initiation of neuronal differentiation. It activates transcription by binding to the E box, the DNA motif 5'-CANNTG-3'. The protein associates with chromatin at enhancer regulatory elements in genes that encode key transcriptional regulators of neurogenesis, placing it near the top of the regulatory cascade that commits cells to a neuronal fate.
The NEUROG1 gene encodes Neurogenin-1, a member of the basic helix-loop-helix (bHLH) group of proteins. Its subcellular location is the nucleus, which fits its role as a DNA-binding regulator. NCBI Gene annotation describes E-box binding activity and protein homodimerization activity, and predicts that the protein is located in chromatin and active in the nucleus.
Beyond neuronal differentiation, the gene is annotated as involved in several developmental processes, including cochlea morphogenesis, cranial nerve development and hard palate morphogenesis. The protein has several aliases, including AKA, Math4C, ngn1, bHLHa6 and NEUROD3. Mouse and rat each have an ortholog named Neurog1, which allows the NEUROG1 protein to be studied in common rodent models. Related neurogenin family members include NEUROG2 and NEUROG3.
NEUROG1 helps initiate neuronal differentiation and binds enhancers of genes encoding key transcriptional regulators of neurogenesis.
It activates transcription through E-box (5'-CANNTG-3') binding, making it a model for studying bHLH factor activity at chromatin.
The gene is annotated as involved in cochlea morphogenesis, linking it to studies of inner ear development.
Annotated roles in cranial nerve development and hard palate morphogenesis make NEUROG1 relevant to craniofacial biology.
NEUROG1 is a transcriptional regulator involved in the initiation of neuronal differentiation. It activates transcription by binding the E box (5'-CANNTG-3') and associates with chromatin at enhancer elements of genes encoding key transcriptional regulators of neurogenesis.
NEUROG1 is the HGNC symbol for neurogenin 1, and the UniProt protein name is Neurogenin-1. Aliases and previous symbols include AKA, Math4C, ngn1, bHLHa6 and NEUROD3. It belongs to the basic helix-loop-helix group of proteins.
Yes. Both mouse and rat have an ortholog called Neurog1, so the gene can be studied in standard rodent models. NCBI annotation links the human gene to cochlea morphogenesis, cranial nerve development and hard palate morphogenesis. Check the datasheet of any product for its validated reactivity.
Other neurogenin family members and bHLH transcription factors involved in neuronal differentiation.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q92886; product specifications from Assay Genie datasheets.