LCP2
LCP2, also known as SLP-76 or SLP76, is a cytoplasmic adapter protein that transmits signals from the T-cell receptor in T-cells and other immune cells. It links receptor-proximal tyrosine kinase activity to downstream effectors that drive cell activation. Browse Assay Genie's current range of LCP2 research reagents below, or read on for the biology behind the target.
LCP2 is an adapter protein with no enzymatic activity of its own. It acts mainly in signalling pathways within T-cells, and also in other immune cells including platelets, mast cells and natural killer (NK) cells. After antigen recognition, it transduces the signal from the T-cell receptor (TCR) and so contributes to T-cell activation. Once phosphorylated by the kinase ZAP70, LCP2 mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK. In turn, it stimulates activation of PKC-theta (PRKCQ) and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation.
The LCP2 gene encodes a substrate of the TCR-activated protein tyrosine kinase pathway. The protein associates with growth factor receptor bound protein 2 and is thought to function in TCR-mediated intracellular signal transduction. UniProt places it in the cytoplasm, and HGNC classifies it in the SH2 domain containing gene group. LCP2 is also reported to be essential in AGER-induced signalling, including p38 MAPK and ERK1/2 activation, which leads to cytokine release and pro-inflammatory responses.
The name derives from the earlier description 'SH2 domain-containing leukocyte protein of 76kD', which gave rise to the alias SLP-76. A similar protein in mouse, encoded by Lcp2, has a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal foetal haemorrhaging, dysfunctional platelets and impaired viability. Researchers studying the LCP2 gene or SLP-76 protein therefore work across T-cell biology, platelet function and inflammatory signalling.
LCP2 transduces TCR signals after antigen recognition and, once phosphorylated by ZAP70, recruits VAV1, NCK and ITK to drive T-cell activation.
As an adapter in T-cells, platelets, mast cells and NK cells, LCP2 is relevant to signalling across several immune cell types.
LCP2 stimulates PKC-theta activation and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation.
LCP2 is essential in AGER-induced p38 MAPK and ERK1/2 activation, leading to cytokine release and pro-inflammatory responses.
LCP2 is an adapter protein that transduces signals from the T-cell receptor after antigen recognition, leading to T-cell activation. When phosphorylated by ZAP70, it mediates interactions with VAV1, NCK and ITK. It also acts in platelets, mast cells and NK cells.
LCP2 is also called SLP-76 or SLP76. The full name is lymphocyte cytosolic protein 2, previously described as SH2 domain-containing leukocyte protein of 76kD. The mouse ortholog is Lcp2. Check the datasheet of any product for its validated reactivity.
Mice lacking Lcp2 show subcutaneous and intraperitoneal foetal haemorrhaging, dysfunctional platelets and impaired viability. A similar protein in mouse also contributes to normal T-cell development and activation, which indicates a conserved role in immune and platelet function.
Related lymphocyte cytosolic protein and immune signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13094; product specifications from Assay Genie datasheets.