LY6G6F
LY6G6F (lymphocyte antigen 6 family member G6F, also known as G6f, NG32, LY6G6D and C6orf21) is a type I transmembrane protein of the immunoglobulin superfamily. It is a cell-surface protein that may act in signal transduction pathways involving GRB2 and GRB7. Browse Assay Genie's current range of LY6G6F research reagents below, or read on for the biology behind the target.
The LY6G6F protein is a type I transmembrane protein that localises to the cell membrane. It belongs to the immunoglobulin (Ig) superfamily, a large group of cell-surface proteins involved in the immune system and in cellular recognition. According to UniProt, LY6G6F may play a role in downstream signal transduction pathways involving the adaptor proteins GRB2 and GRB7, although its precise mechanism is not defined in the sources used here.
The LY6G6F gene is assigned by HGNC to two gene groups: V-set domain containing, and LY6/PLAUR domain containing. These groupings place it alongside other proteins that share these structural domains. The protein is also referred to as G6f, a name used in the original characterisation of the human protein, and as NG32.
The gene has had several earlier designations. It was previously known as chromosome 6 open reading frame 21 (C6orf21), and as lymphocyte antigen 6 complex, locus G6F. LY6G6D also appears among its previous symbols. A rat ortholog, Ly6g6f, is recorded for the gene. Researchers studying LY6G6F, whether by LY6G6F antibody-based detection or by measuring the LY6G6F protein in other ways, should use these aliases when searching the literature, as older papers may use any of them.
As a type I transmembrane Ig superfamily protein, LY6G6F belongs to a class of cell-surface proteins involved in immune function and cellular recognition.
LY6G6F may participate in downstream signalling pathways involving GRB2 and GRB7, making it relevant to studies of adaptor-protein signalling.
HGNC places LY6G6F in the LY6/PLAUR domain containing group, supporting comparative work across related family members.
Multiple aliases and a rat ortholog, Ly6g6f, make LY6G6F a useful case for cross-species and literature-mapping studies.
LY6G6F is a type I transmembrane protein of the Ig superfamily found at the cell membrane. UniProt notes that it may play a role in downstream signal transduction pathways involving GRB2 and GRB7. Its function is described cautiously, and further experimental work is needed to define it.
LY6G6F is also called G6f, NG32, LY6G6D and C6orf21. Earlier HGNC names were chromosome 6 open reading frame 21 and lymphocyte antigen 6 complex, locus G6F. Checking all of these aliases is useful when searching older publications or databases.
A rat ortholog, Ly6g6f, is recorded for the human LY6G6F gene. No mouse ortholog is listed in the data used for this page. Researchers working in animal models should confirm the relevant ortholog, and check the datasheet of any product for its validated reactivity.
Other LY6 family members, LY6/PLAUR domain proteins and lymphocyte antigens with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q5SQ64; product specifications from Assay Genie datasheets.