PPY
PPY (pancreatic polypeptide, also known as PNP) is a secreted hormone of the neuropeptide Y family. It is released by pancreatic cells and regulates pancreatic and gastrointestinal functions, with a proposed role in controlling food intake. Browse Assay Genie's current range of PPY research reagents below, or read on for the biology behind the target.
PPY is a hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions. UniProt annotates its action as probably mediated through signalling by the G protein-coupled receptor NPY4R2. The hormone may also be important in the regulation of food intake, which has made it a subject of interest in appetite and energy-balance research.
The PPY gene encodes a member of the neuropeptide Y (NPY) family of peptides and belongs to the HGNC gene group of neuropeptides. The encoded preproprotein is synthesised in the pancreatic islets of Langerhans and is proteolytically processed into two peptide products: the active pancreatic hormone of 36 amino acids and an icosapeptide whose function is unknown. The mature product is secreted. Alternative splicing produces multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. Orthologues of the PPY gene are present in mouse and rat (both Ppy).
Studies summarised by NCBI Gene link circulating PPY levels to feeding state. Plasma levels of the hormone are reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In obese rodents, infusion of the hormone has been shown to decrease weight gain. The protein is also known by the alias PNP, and researchers studying PPY biology often work alongside other NPY family peptides and their receptors.
PPY may be important in regulating food intake, and its plasma levels change with conditions of increased intake and in anorexia nervosa.
Infusion of the hormone in obese rodents has been shown to decrease weight gain, making it relevant to energy-balance models.
PPY acts as a regulator of gastrointestinal functions, providing a route into studies of gut hormone signalling.
The preproprotein is synthesised in the islets of Langerhans, so PPY is relevant to studies of pancreatic endocrine function.
PPY is a hormone secreted by pancreatic cells that regulates pancreatic and gastrointestinal functions, probably by signalling through the G protein-coupled receptor NPY4R2. It may also be important in the regulation of food intake, according to the NCBI Gene summary.
PPY stands for pancreatic polypeptide and has the alias PNP. The 95 amino acid preproprotein is processed into the active 36 amino acid hormone and an icosapeptide of unknown function. Alternative splicing gives multiple transcript variants.
Mouse and rat both have a Ppy orthologue; check the datasheet of any product for its validated reactivity. PPY belongs to the NPY family. Plasma levels are elevated in anorexia nervosa and reduced in conditions with increased food intake.
Other NPY family peptides, their G protein-coupled receptors and related markers of appetite and gut hormone signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P01298; product specifications from Assay Genie datasheets.