ATP2A3
ATP2A3, also known as SERCA3 or sarcoplasmic/endoplasmic reticulum calcium ATPase 3, is a magnesium-dependent P-type ATPase that couples ATP hydrolysis to calcium transport. It moves calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Browse Assay Genie's current range of ATP2A3 research reagents below, or read on for the biology behind the target.
ATP2A3 is a magnesium-dependent enzyme that catalyses the hydrolysis of ATP coupled with the transport of calcium. It transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen, and in doing so contributes to the calcium sequestration involved in muscular excitation and contraction. The protein is one of the SERCA Ca(2+)-ATPases, a group of intracellular pumps located in the sarcoplasmic or endoplasmic reticula.
UniProt places ATP2A3 in the cation transport ATPase (P-type) family, type IIA subfamily. The protein is found in the nuclear membrane, the endoplasmic reticulum membrane and the sarcoplasmic reticulum membrane. The ATP2A3 gene is a member of the HGNC group of Ca2+ transporting ATPases, alongside ATP2A1 and ATP2A2, and has mouse and rat orthologs that share the symbol Atp2a3. Alternative splicing of the gene produces multiple transcript variants that encode different isoforms, which is worth bearing in mind when selecting reagents for a particular form of the protein.
The gene was previously named ATPase, Ca++ transporting, ubiquitous, and SERCA3 remains a widely used alias. Researchers studying intracellular calcium handling, store filling and excitation-contraction coupling use ATP2A3 as a marker and a point of comparison with the other SERCA pumps. Reagents for the ATP2A3 gene product, including any ATP2A3 antibody or ATP2A3 ELISA kit, support work on calcium homeostasis at the reticulum membrane.
ATP2A3 pumps cytosolic calcium into the sarcoplasmic/endoplasmic reticulum lumen, making it a relevant target for studies of intracellular calcium handling.
The pump contributes to calcium sequestration involved in muscular excitation and contraction, supporting research on muscle physiology.
As a type IIA P-type ATPase, ATP2A3 is used to study ATP-coupled cation transport and comparison across SERCA family members.
Alternative splicing yields multiple isoforms, so ATP2A3 is useful for investigating how transcript variants relate to pump expression and function.
ATP2A3 is a magnesium-dependent enzyme that catalyses ATP hydrolysis coupled with calcium transport. It moves calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen and contributes to calcium sequestration involved in muscular excitation and contraction.
Yes. SERCA3 is an alias for ATP2A3, and the protein is also named sarcoplasmic/endoplasmic reticulum calcium ATPase 3. The gene was previously called ATPase, Ca++ transporting, ubiquitous. Alternative splicing gives multiple transcript variants that encode different isoforms.
Mouse and rat both have an ortholog named Atp2a3. In humans, ATP2A3 belongs to the Ca2+ transporting ATPase gene group with ATP2A1 and ATP2A2. Check the datasheet of any product for its validated reactivity.
Other SERCA pumps, calcium and cation-transporting ATPases and related P-type ATPase targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q93084; product specifications from Assay Genie datasheets.