NBL1
NBL1 (neuroblastoma suppressor of tumorigenicity 1, also known as DAN, DAND1, NO3 and NB) is a secreted member of the DAN family. It acts as a bone morphogenetic protein (BMP) antagonist and is a candidate tumour suppressor in neuroblastoma. Browse Assay Genie's current range of NBL1 research reagents below, or read on for the biology behind the target.
NBL1 is a secreted protein that functions as an antagonist of bone morphogenetic proteins (BMPs). According to the NCBI Gene summary, it binds to BMPs and prevents them from interacting with their receptors, and it may therefore play an important role during growth and development. UniProt also describes NBL1 as a possible candidate tumour suppressor gene of neuroblastoma, which may help prevent cells from entering the final G1/S stage of the transformation process.
The NBL1 gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins. Members of this family contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signalling molecules. HGNC classifies the gene within the DAN family, and the protein is annotated as belonging to that family in UniProt. Orthologous genes are named Nbl1 in both mouse and rat. Alternatively spliced transcript variants have been identified for the NBL1 gene, and read-through transcripts have been observed between this locus and the upstream mitochondrial inner membrane organizing system 1 gene.
The name reflects the gene's early association with neuroblastoma. HGNC lists previous names including neuroblastoma, suppression of tumorigenicity 1, and neuroblastoma 1, DAN family BMP antagonist. Aliases such as DAN, DAND1, NO3, NB and D1S1733E appear in the literature, so it is worth searching under several names when reviewing studies of NBL1 protein or NBL1 antibody use.
NBL1 binds BMPs and prevents receptor engagement, making it a useful target for studying how extracellular antagonists regulate BMP pathway activity.
UniProt describes NBL1 as a candidate tumour suppressor of neuroblastoma, linking it to studies of cell transformation and the G1/S transition.
As a BMP antagonist, NBL1 may play an important role during growth and development, supporting work on secreted developmental regulators.
As the founding member of the CAN family, NBL1 is a reference point for comparing cystine knot-containing secreted antagonists.
NBL1 is a secreted protein that acts as a BMP antagonist, binding bone morphogenetic proteins and preventing them from interacting with their receptors. UniProt also lists it as a possible tumour suppressor candidate in neuroblastoma that may help stop cells entering the G1/S stage of transformation.
The gene was first named for neuroblastoma suppression of tumorigenicity. HGNC records aliases and previous symbols including D1S1733E, NB, DAN, NO3 and DAND1, and the earlier name neuroblastoma 1, DAN family BMP antagonist. The current approved name is NBL1, DAN family BMP antagonist.
NBL1 is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family, and orthologues named Nbl1 exist in mouse and rat. Check the datasheet of any product for its validated reactivity.
Other DAN family members, BMP ligands and BMP antagonists studied alongside NBL1.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P41271; product specifications from Assay Genie datasheets.