STMN2
STMN2 (stathmin 2, also known as SCG10 or SCGN10) is a member of the stathmin family of phosphoproteins that regulates microtubule stability. It plays a regulatory role in neuronal growth and controls neurite length in cortical neurons. Browse Assay Genie's current range of STMN2 research reagents below, or read on for the biology behind the target.
STMN2 is a regulator of microtubule stability. Stathmin proteins function in microtubule dynamics and signal transduction, and STMN2 is regulated by phosphorylation. When phosphorylated by MAPK8, it stabilises microtubules and so controls neurite length in cortical neurons. In the developing brain, it negatively regulates the rate of exit from the multipolar stage and retards radial migration from the ventricular zone.
The STMN2 gene encodes a member of the stathmin family, listed by HGNC in the Stathmins gene group. The protein is found in several cellular compartments: the cytoplasm, including the perinuclear region, the growth cone and axon, the Golgi apparatus, endosomes, lamellipodia and membranes. Alternatively spliced transcript variants have been observed for the gene, and a pseudogene is located on the long arm of chromosome 6. The mouse and rat orthologues are both named Stmn2.
The protein is also known as stathmin-like 2, SCG10 and SCGN10. Beyond its role in neuronal growth, it is thought to be involved in osteogenesis. Reduced expression of the gene has been associated with Down's syndrome and Alzheimer's disease, which makes STMN2 a frequent subject in neurodevelopment and neurodegeneration research. Researchers studying the STMN2 protein often consider it alongside STMN1, another stathmin family member.
STMN2 plays a regulatory role in neuronal growth and controls neurite length in cortical neurons through microtubule stabilisation.
In the developing brain, STMN2 regulates exit from the multipolar stage and slows radial migration from the ventricular zone.
As a stathmin family member, STMN2 functions in microtubule dynamics and signal transduction, including regulation by MAPK8 phosphorylation.
Reduced STMN2 expression has been associated with Down's syndrome and Alzheimer's disease, making it relevant to disease studies.
STMN2 regulates microtubule stability. When phosphorylated by MAPK8, it stabilises microtubules and controls neurite length in cortical neurons. In the developing brain it slows the exit from the multipolar stage and retards radial migration from the ventricular zone.
STMN2 is also called SCG10 and SCGN10, and its previous name was stathmin-like 2. UniProt lists the protein as Stathmin-2. Alternatively spliced transcript variants have been observed for the gene, so check the datasheet of any product for its validated reactivity.
Reduced STMN2 expression has been associated with Down's syndrome and Alzheimer's disease. The gene has orthologues in mouse and rat, both named Stmn2, and a pseudogene lies on the long arm of chromosome 6 in humans.
Other stathmin family members involved in microtubule dynamics and neuronal signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q93045; product specifications from Assay Genie datasheets.