PRPH
PRPH (peripherin) is a class III neuronal intermediate filament protein found in neurons of the peripheral nervous system. Also known as PRPH1 and NEF4, it contributes to the neuronal cytoskeleton and to the development of unmyelinated sensory neurons. Browse Assay Genie's current range of PRPH research reagents below, or read on for the biology behind the target.
PRPH is a class III neuronal intermediate filament protein. It may form an independent structural network without the involvement of other neurofilaments, or it may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to build a filamentous network. Assembly of neuronal intermediate filaments may be regulated by RAB7A. Within the cell, the protein is located in the cytoskeleton, in the axon and in the perikaryon.
Functionally, peripherin plays a role in the development of unmyelinated sensory neurons. It may also be involved in axon elongation and in axon regeneration after injury. In type II spiral ganglion neurons of the cochlea, it inhibits neurite extension. The PRPH gene encodes a cytoskeletal protein that belongs to the intermediate filament family and is found in neurons of the peripheral nervous system. It has homology to other cytoskeletal proteins such as desmin.
The PRPH gene is listed by HGNC in the group of type III intermediate filaments, and the mouse and rat orthologs are both named Prph. NCBI Gene notes that this protein is distinct from the peripherin found in photoreceptors. Mutations in the gene have been associated with susceptibility to amyotrophic lateral sclerosis, which makes peripherin a point of interest in studies of neuronal cytoskeleton biology and neurodegeneration.
PRPH is a type III neuronal intermediate filament that may assemble alone or with NEFL, NEFH, NEFM and INA into filamentous networks.
Peripherin has a role in the development of unmyelinated sensory neurons, making it relevant to studies of the peripheral nervous system.
PRPH may be involved in axon elongation and in axon regeneration after injury.
Mutations in PRPH have been associated with susceptibility to amyotrophic lateral sclerosis, linking the gene to motor neuron disease studies.
PRPH is a class III neuronal intermediate filament protein. It may form its own structural network or cooperate with NEFL, NEFH, NEFM and INA. It plays a role in the development of unmyelinated sensory neurons and may be involved in axon elongation and regeneration after injury.
The gene symbol PRPH stands for peripherin. It is also known as PRPH1 and NEF4. NCBI Gene points out that this neuronal protein is a different protein from the peripherin found in photoreceptors, so context matters when searching the literature.
Mutations in PRPH have been associated with susceptibility to amyotrophic lateral sclerosis. Orthologs exist in mouse and rat, both named Prph. Check the datasheet of any product for its validated reactivity.
Other neuronal intermediate filament proteins and regulators that interact with peripherin, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P41219; product specifications from Assay Genie datasheets.