NPR3
NPR3 (natriuretic peptide receptor 3, also known as NPRC, ANPRC and GUCY2B) is a cell membrane receptor for the natriuretic peptide hormones. It is thought to act as a clearance receptor, regulating the local concentrations and effects of these peptides. Browse Assay Genie's current range of NPR3 research reagents below, or read on for the biology behind the target.
NPR3 is a receptor for the natriuretic peptide hormones. It binds atrial natriuretic peptide (NPPA/ANP), brain natriuretic peptide (NPPB/BNP) and C-type natriuretic peptide (NPPC/CNP) with similar affinities. It may function as a clearance receptor for all three, regulating their local concentrations and effects. According to the NCBI Gene summary, the receptor clears circulating and extracellular natriuretic peptides through endocytosis of the receptor.
NPR3 also regulates osteoblast differentiation and bone growth. It binds its ligand osteocrin, which prevents natriuretic peptides from binding NPR3 (also written NPR-C). The result is increased cGMP production. Natriuretic peptides are small peptides that regulate blood volume and pressure, pulmonary hypertension and cardiac function, as well as some metabolic and growth processes. This makes the NPR3 gene relevant to cardiovascular, metabolic and skeletal research.
NPR3 is one of three natriuretic peptide receptors and belongs to the ANF receptor family. Its gene has several transcript variants that encode different isoforms. The HGNC places it in the DENN domain containing gene group. Earlier names include atrionatriuretic peptide receptor C, natriuretic peptide receptor C/guanylate cyclase C and chromosome 5 open reading frame 23 (C5orf23). Related family members include NPR1 and NPR2. Mouse and rat both have an Npr3 ortholog, so the protein can be studied in common rodent models.
Natriuretic peptides regulate blood volume, blood pressure, pulmonary hypertension and cardiac function, and NPR3 controls their local concentrations.
NPR3 clears circulating and extracellular natriuretic peptides through receptor endocytosis, making it a focus for studies of ANP, BNP and CNP turnover.
NPR3 regulates osteoblast differentiation and bone growth by binding osteocrin, which blocks natriuretic peptide binding and increases cGMP production.
Natriuretic peptides influence some metabolic and growth processes, so NPR3 is relevant to how these hormone signals are shaped.
NPR3 is a cell membrane receptor that binds ANP, BNP and CNP with similar affinities. It may act as a clearance receptor, regulating their local concentrations and effects. It also binds osteocrin, which affects osteoblast differentiation and bone growth by increasing cGMP production.
NPR3 is also called NPRC, ANPRC, GUCY2B, FLJ14054 and C5orf23. Earlier names include atrionatriuretic peptide receptor C and natriuretic peptide receptor C/guanylate cyclase C. The UniProt protein name is atrial natriuretic peptide receptor 3. Multiple transcript variants encode different isoforms.
Yes. The mouse and rat orthologs are both named Npr3, so the receptor can be studied in standard rodent models. NPR3 is one of three natriuretic peptide receptors and belongs to the ANF receptor family. Check the datasheet of any product for its validated reactivity.
Other natriuretic peptide receptors that work alongside NPR3 in natriuretic peptide signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P17342; product specifications from Assay Genie datasheets.