CST9L
CST9L (cystatin 9 like, also known as bA218C14.1 and CTES7B) is a secreted member of the type 2 cystatin group, a class of cysteine proteinase inhibitors. The CST9L gene lies in the cystatin locus on chromosome 20 and is expressed in the testis. Browse Assay Genie's current range of CST9L research reagents below, or read on for the biology behind the target.
CST9L belongs to the cystatin superfamily, which encompasses proteins containing multiple cystatin-like sequences. Some members of the superfamily are active cysteine protease inhibitors, while others have lost, or perhaps never acquired, this inhibitory activity. The superfamily includes three inhibitory families: the type 1 cystatins (stefins), the type 2 cystatins and the kininogens. CST9L is classed with the type 2 cystatins, a group of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The protein is annotated as secreted.
The CST9L gene sits in the cystatin locus on chromosome 20, which contains the majority of the type 2 cystatin genes and pseudogenes. It encodes a protein similar to mouse cystatin 9, which is reflected in its HGNC name, cystatin 9 like, and its previous name, cystatin 9 (mouse)-like. Other symbols associated with the gene are bA218C14.1 and CTES7B.
Based on its testis-specific expression, CST9L is likely to have a role in tissue reorganisation during early testis development. No specific function annotation is currently curated in UniProt for the CST9L protein, so its activity as a protease inhibitor has not been defined in the sources used here. Researchers studying CST9L often compare it with neighbouring cystatin genes, such as CST9 and CSTL1, to place it within the wider cystatin locus and the biology of the male reproductive tract.
CST9L shows testis-specific expression and is likely to contribute to tissue reorganisation during early testis development.
As a type 2 cystatin, CST9L helps researchers explore which cystatin-like proteins act as cysteine protease inhibitors and which have lost that activity.
The CST9L gene lies in the chromosome 20 cystatin locus, which holds most type 2 cystatin genes and pseudogenes.
Type 2 cystatins are found in human fluids and secretions, and CST9L is annotated as a secreted protein.
CST9L is a type 2 cystatin family member, a class generally described as cysteine proteinase inhibitors. Its precise activity is not annotated. Because its expression is testis-specific, it is likely to play a role in tissue reorganisation during early testis development.
The HGNC name is cystatin 9 like, and the UniProt name is Cystatin-9-like. Aliases include bA218C14.1 and CTES7B. The gene was previously named cystatin 9 (mouse)-like, because the encoded protein is similar to mouse cystatin 9.
Yes. CST9L belongs to the cystatin family and the type 2 cystatin gene group, and its gene lies in the cystatin locus on chromosome 20 with most other type 2 cystatin genes. Check the datasheet of any product for its validated reactivity.
Other cystatin family members, including type 2 cystatins from the chromosome 20 locus, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H4G1; product specifications from Assay Genie datasheets.