FOXF1
FOXF1 (forkhead box F1, also known as FREAC1 or FKHL5) is a member of the forkhead family of transcription factors. It is a probable transcription activator for a number of lung-specific genes and may contribute to embryonic development. Browse Assay Genie's current range of FOXF1 research reagents below, or read on for the biology behind the target.
FOXF1 is a probable transcription activator for a number of lung-specific genes. As a transcription factor it acts in the nucleus, where it is thought to regulate gene expression. The NCBI Gene summary notes that the specific function of the gene has not yet been fully determined, but that it may play a role in the regulation of pulmonary genes as well as in embryonic development.
The FOXF1 gene belongs to the forkhead family of transcription factors, which is characterised by a distinct forkhead domain. In HGNC it sits within the gene group of forkhead boxes. The encoded forkhead box protein F1 is catalogued in UniProt under accession Q12946, and the mouse ortholog is Foxf1, which allows the gene to be studied in murine models.
The gene has been known under the aliases FREAC1 and FKHL5, and researchers may encounter these names in older literature. Because the evidence for FOXF1 centres on lung-specific gene regulation and development, it is most often considered in studies of pulmonary biology and transcriptional control. Related forkhead family members, such as FOXF2, are useful points of comparison when examining how forkhead factors differ in their roles.
FOXF1 is a probable transcription activator for a number of lung-specific genes, making it a focus for studies of pulmonary transcriptional control.
The NCBI Gene summary indicates FOXF1 may play a role in embryonic development, supporting its study in developmental biology.
As a member of the forkhead family defined by the forkhead domain, FOXF1 is used to explore how forkhead factors function and differ.
FOXF1 acts as a nuclear transcription activator, so it is relevant to work on gene expression control and transcriptional networks.
FOXF1 is a probable transcription activator for a number of lung-specific genes. The NCBI Gene summary adds that it may play a role in regulating pulmonary genes and in embryonic development, although its specific function has not yet been fully determined.
FOXF1 stands for forkhead box F1. It has also been called FREAC1 and FKHL5. UniProt lists the protein as forkhead box protein F1, and HGNC places the gene in the forkhead boxes group.
A mouse ortholog, Foxf1, is recorded for the human gene, so murine systems can be used to study it. No rat ortholog is given in the data supplied. Check the datasheet of any product for its validated reactivity.
Other forkhead box transcription factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q12946; product specifications from Assay Genie datasheets.