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Anti-FOXF1 Antibody (CAB6513)

SKU:
CAB6513
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ACDMPV
FKHL5
FREAC1
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
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Description

Product Name:FOXF1 Rabbit mAb
Product Code:CAB6513
Size:20uL, 50uL, 100uL
Synonyms:ACDMPV, FKHL5, FREAC1
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human FOXF1
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U2OS, Mouse lung
Immunogen:A synthesized peptide derived from human FOXF1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2294
Uniprot:Q12946
Calculated MW:40kDa
Observed MW:40KDa
UniProt Protein Function:FOXF1: Probable transcription activator for a number of lung- specific genes. Defects in FOXF1 are the cause of alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV). ACDMPV is a rare malformation due to abnormal development of the capillary vascular system in the lungs. Histologically, it is characterized by failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.
UniProt Protein Details:

Protein type:DNA-binding; Motility/polarity/chemotaxis; Transcription factor

Chromosomal Location of Human Ortholog: 16q24

Cellular Component: nucleus; transcription factor complex

Molecular Function:DNA binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding

Biological Process: blood vessel development; embryonic digestive tract morphogenesis; embryonic ectodermal gut morphogenesis; gut development; heart development; in utero embryonic development; lung development; midgut development; morphogenesis of a branching structure; pancreas development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; respiratory tube development

Disease: Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins

NCBI Summary:This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]
UniProt Code:Q12946
NCBI GenInfo Identifier:238054293
NCBI Gene ID:2294
NCBI Accession:Q12946.2
UniProt Secondary Accession:Q12946,Q5FWE5, B2RAF4,
UniProt Related Accession:Q12946
Molecular Weight:40,122 Da
NCBI Full Name:Forkhead box protein F1
NCBI Synonym Full Names:forkhead box F1
NCBI Official Symbol:FOXF1  
NCBI Official Synonym Symbols:FKHL5; ACDMPV; FREAC1  
NCBI Protein Information:forkhead box protein F1
UniProt Protein Name:Forkhead box protein F1
UniProt Synonym Protein Names:Forkhead-related activator 1; FREAC-1; Forkhead-related protein FKHL5; Forkhead-related transcription factor 1
Protein Family:Forkhead box protein
UniProt Gene Name:FOXF1  
UniProt Entry Name:FOXF1_HUMAN

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