Pax7
Pax7 (paired box 7, also known as Hup1) is a nuclear transcription factor of the paired homeobox family. It regulates the proliferation of muscle stem cells and has a role in myogenesis and muscle regeneration. Browse Assay Genie's current range of Pax7 research reagents below, or read on for the biology behind the target.
Pax7 is a transcription factor involved in the regulation of muscle stem cell proliferation. Through this activity it plays a role in myogenesis and in muscle regeneration. The protein is found in the nucleus, consistent with its function in controlling gene expression.
The PAX7 gene is a member of the paired box (PAX) family of transcription factors. Members of this family typically contain a paired box domain, an octapeptide and a paired-type homeodomain, and UniProt places the Pax7 protein in the paired homeobox family. HGNC classifies the gene within the PRD class homeoboxes and pseudogenes and the paired boxes gene groups. Three transcript variants encoding different isoforms have been reported for this gene. Researchers working with a Pax7 antibody, Pax7 ELISA kit or Pax7 protein reagent will find a mouse ortholog, also named Pax7.
PAX genes play critical roles during foetal development and cancer growth. The specific function of the paired box 7 gene is described by RefSeq as unknown, but tumour suppression has been speculated. This is because fusion of the gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. The gene was previously named paired box gene 7 and carries the alias Hup1.
Pax7 is involved in regulating the proliferation of muscle stem cells, making it a central target for studying how these cells are controlled.
Pax7 plays a role in myogenesis and muscle regeneration, so it is relevant to studies of how muscle forms and repairs.
Fusion of the PAX7 gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma.
PAX family genes play critical roles in foetal development and cancer growth, placing Pax7 within wider studies of these processes.
Pax7 is a transcription factor that regulates the proliferation of muscle stem cells. It plays a role in myogenesis and muscle regeneration. It is localised to the nucleus and belongs to the paired homeobox family of proteins.
Pax7 is the paired box 7 gene product, listed by UniProt as Paired box protein Pax-7. It carries the alias Hup1 and was previously named paired box gene 7. Three transcript variants encoding different isoforms have been found.
Fusion of the PAX7 gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Its specific function is described as unknown, with tumour suppression speculated. A mouse ortholog, Pax7, exists; check the datasheet of any product for its validated reactivity.
Other paired box transcription factors from the PAX family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P23759; product specifications from Assay Genie datasheets.