PSIP1
PSIP1 (PC4 and SRSF1 interacting protein 1) is a nuclear transcriptional coactivator of the HDGF family, also known as LEDGF, p75, p52 and DFS70. It contributes to neuronal and lens cell differentiation, stress responses and splicing, and acts as a cellular cofactor for lentiviral integration. Browse Assay Genie's current range of PSIP1 research reagents below, or read on for the biology behind the target.
PSIP1 is a transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. It has a particular role in gene regulation and stress responses in lens epithelial cells, and it may be important in the terminal differentiation of lens epithelial cells into fibre cells. It may also play a protective role during stress-induced apoptosis. In addition, PSIP1 serves as a cellular cofactor for lentiviral integration.
The two main forms differ in activity. Isoform 2 (p52) is described as a more general and stronger transcriptional coactivator, and it may also act as an adapter that coordinates pre-mRNA splicing. NCBI Gene annotation lists DNA-binding transcription factor binding, chromatin binding and transcription coactivator activity for the PSIP1 gene. The protein is involved in mRNA 5'-splice site recognition and in positive regulation of transcription by RNA polymerase II. It is located in heterochromatin, at the nuclear periphery and in the nucleoplasm.
PSIP1 belongs to the HDGF family, and HGNC places it in the heparin binding growth factor family group. The name reflects its identification as a PC4 and SFRS1-interacting protein, and earlier HGNC names include PC4 and SFRS1 interacting protein 2 and PC4 and SFRS1 interacting protein 1. Aliases such as LEDGF, p75, p52, DFS70 and PSIP2 appear throughout the literature. Mouse and rat both carry a Psip1 ortholog, which supports comparative work on this nuclear protein.
PSIP1 is a transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis.
It regulates genes in lens epithelial cells and may support their terminal differentiation into fibre cells.
Isoform 2 is a strong coactivator and may act as an adapter coordinating pre-mRNA splicing.
PSIP1 functions as a cellular cofactor for lentiviral integration, making it relevant to host-virus studies.
PSIP1 is a nuclear transcriptional coactivator involved in neuroepithelial stem cell differentiation, neurogenesis, lens epithelial gene regulation and stress responses. It may protect cells during stress-induced apoptosis and acts as a cellular cofactor for lentiviral integration. Check the datasheet of any product for its validated reactivity.
Aliases include p52, LEDGF, p75, DFS70 and PSIP2. Isoform 2 is the stronger general coactivator and may coordinate pre-mRNA splicing. Earlier HGNC names were PC4 and SFRS1 interacting protein 2 and PC4 and SFRS1 interacting protein 1.
Yes. Mouse and rat each have an ortholog named Psip1, so the human protein can be studied alongside rodent models. As a member of the HDGF family, it is a nuclear protein. Check the datasheet of any product for its validated reactivity.
Other HDGF family members, splicing factors and transcriptional coactivators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75475; product specifications from Assay Genie datasheets.