MMP28
MMP28 (matrix metallopeptidase 28, also known as epilysin, MMP-28, MMP-25 and MM28) is a secreted member of the matrix metalloproteinase family. It can degrade casein and is thought to contribute to tissue homeostasis and repair. Browse Assay Genie's current range of MMP28 research reagents below, or read on for the biology behind the target.
MMP28 is a secreted endopeptidase that belongs to the peptidase M10A family. Like other proteins of the matrix metalloproteinase (MMP) family, it is involved in the breakdown of extracellular matrix. The UniProt annotation records that MMP28 can degrade casein and could play a role in tissue homeostasis and repair. The protein is found in the extracellular space and extracellular matrix, where it acts on its substrates.
The MMP28 gene encodes the enzyme, and alternative splicing of the gene results in multiple transcript variants. The NCBI Gene summary notes that the expression pattern of MMP28 suggests a role in tissue homeostasis and in wound repair. Researchers studying the MMP28 protein often look at how it fits alongside other MMPs in matrix turnover. The gene sits within the HGNC group of M10 matrix metallopeptidases.
The wider MMP family contributes to normal physiological processes such as embryonic development, reproduction and tissue remodelling. It also contributes to disease processes, including asthma and metastasis. MMP28 is also called epilysin, and has the previous symbols MMP-25 and MM28, as well as the previous name matrix metalloproteinase 28. Take care to distinguish these names from other family members when you search the literature, because some symbols overlap. An MMP28 antibody or MMP28 ELISA kit should be chosen with this in mind.
MMP28 is proposed to help maintain tissue homeostasis, making it a candidate for studies of normal extracellular matrix turnover.
Its expression pattern suggests a role in wound repair, so MMP28 is relevant to work on tissue repair mechanisms.
As an MMP family member, MMP28 is involved in extracellular matrix breakdown, a process central to development, reproduction and remodelling.
MMP28 is a peptidase M10A enzyme that degrades casein, useful for comparing substrate activity across matrix metalloproteinases.
MMP28 is a secreted matrix metalloproteinase that can degrade casein. Its expression pattern suggests roles in tissue homeostasis and wound repair. Like other MMPs, it is involved in breaking down extracellular matrix, and the protein is located in the extracellular space and matrix.
MMP28 is also known as epilysin, MMP-28, MMP-25 and MM28. Its full name is matrix metallopeptidase 28, formerly matrix metalloproteinase 28. The gene produces multiple transcript variants through alternative splicing, so check which form a reagent targets.
The MMP family is linked to processes such as embryonic development and tissue remodelling, and to disease processes including asthma and metastasis. For MMP28 specifically, the sources describe a likely role in tissue homeostasis and wound repair. Check the datasheet of any product for its validated reactivity.
Other matrix metalloproteinases and extracellular matrix remodelling enzymes with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H239; product specifications from Assay Genie datasheets.