SLC2A3
SLC2A3, also known as GLUT3, is a facilitative glucose transporter of the solute carrier family 2. It carries glucose and several other monosaccharides across the cell membrane and is required for mesendoderm differentiation. Browse Assay Genie's current range of SLC2A3 research reagents below, or read on for the biology behind the target.
SLC2A3 is a facilitative glucose transporter. It mediates the uptake of glucose across the cell membrane, and can also transport other monosaccharides, including 2-deoxyglucose, galactose, mannose, xylose and fucose. It probably also transports dehydroascorbate. It does not mediate fructose transport. Gene annotation describes D-glucose binding, hexose transmembrane transporter activity and dehydroascorbic acid transmembrane transporter activity, and a role in D-glucose import across the plasma membrane, galactose transmembrane transport and transport across the blood-brain barrier.
The SLC2A3 protein belongs to the major facilitator superfamily, in the sugar transporter (TC 2.A.1.1) family and the glucose transporter subfamily. UniProt places it at the cell membrane, the perikaryon and cell projections, and NCBI Gene lists it as located in the plasma membrane. The SLC2A3 gene is a member of the HGNC gene group solute carrier family 2, and orthologues are named Slc2a3 in both mouse and rat. Studies of the SLC2A3 gene and protein therefore translate readily to rodent models.
SLC2A3 is widely known as GLUT3, and its earlier HGNC name was solute carrier family 2 (facilitated glucose transporter), member 3. Beyond transport, UniProt reports that the protein is required for mesendoderm differentiation. NCBI Gene lists SLC2A3 as a biomarker of Alzheimer's disease, acanthosis nigricans, diabetes mellitus and type 2 diabetes mellitus, which links glucose transport to research in neurodegeneration and metabolic disease.
SLC2A3 mediates facilitative uptake of glucose and other hexoses across the cell membrane, making it a core target for studying sugar transport.
Gene annotation links SLC2A3 to transport across the blood-brain barrier, relevant to how glucose reaches neural tissue.
SLC2A3 is required for mesendoderm differentiation, so it is studied in early lineage specification.
SLC2A3 is reported as a biomarker of Alzheimer's disease, diabetes mellitus and type 2 diabetes mellitus.
SLC2A3 is a facilitative glucose transporter that moves glucose across the cell membrane. It can also take up 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably dehydroascorbate, but not fructose. UniProt also reports that it is required for mesendoderm differentiation.
Yes. GLUT3 is the common alias for SLC2A3, the HGNC symbol for solute carrier family 2 member 3. The previous HGNC name was solute carrier family 2 (facilitated glucose transporter), member 3. UniProt lists the protein as solute carrier family 2, facilitated glucose transporter member 3.
Mouse and rat both have an orthologue named Slc2a3, so rodent models can be used; check the datasheet of any product for its validated reactivity. NCBI Gene lists SLC2A3 as a biomarker of Alzheimer's disease, acanthosis nigricans, diabetes mellitus and type 2 diabetes mellitus.
Other solute carrier family members and membrane transporters involved in nutrient and metabolite transport, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P11169; product specifications from Assay Genie datasheets.