CHMP2B
CHMP2B (charged multivesicular body protein 2B) is a probable core component of the ESCRT-III complex, which drives multivesicular body formation and the sorting of endosomal cargo. It is also known as CHMP2.5, VPS2B and DKFZP564O123. Browse Assay Genie's current range of CHMP2B research reagents below, or read on for the biology behind the target.
CHMP2B is a probable core component of the endosomal sorting complex required for transport III (ESCRT-III). This complex is involved in forming multivesicular bodies (MVBs) and in sorting endosomal cargo proteins into them. MVBs contain intraluminal vesicles, which are generated by invagination and scission from the limiting membrane of the endosome. Most are delivered to lysosomes, where membrane proteins such as stimulated growth factor receptors, lysosomal enzymes and lipids are degraded. The MVB pathway appears to need the sequential action of ESCRT-0, -I, -II and -III complexes, and ESCRT-III proteins mostly dissociate from the invaginating membrane before the vesicle is released.
The ESCRT machinery also acts in topologically equivalent membrane fission events, including the terminal stages of cytokinesis and the budding of enveloped viruses such as HIV-1 and other lentiviruses. ESCRT-III proteins are believed to mediate the vesicle extrusion and membrane fission involved, possibly together with the AAA ATPase VPS4. The CHMP2B protein is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes, and it belongs to the SNF7 family. According to NCBI Gene, it is expressed in neurons of all major regions of the brain.
The CHMP2B gene is a member of the HGNC charged multivesicular body proteins group, within ESCRT-III, and was previously named chromatin modifying protein 2B. Mutations in the gene result in one form of familial frontotemporal lobar degeneration, which makes CHMP2B a point of interest for researchers studying endosomal trafficking in neurons. A mouse ortholog, Chmp2b, is recorded.
CHMP2B is a probable ESCRT-III core component involved in MVB formation and the sorting of endosomal cargo proteins.
ESCRT-III acts in the recycling or degradation of cell surface receptors, including stimulated growth factor receptors routed to lysosomes.
Mutations in the CHMP2B gene cause one form of familial frontotemporal lobar degeneration, and the protein is expressed in neurons across the brain.
The ESCRT machinery contributes to cytokinesis and to the budding of enveloped viruses such as HIV-1, so CHMP2B is relevant to these fission events.
CHMP2B is a probable core component of ESCRT-III. It is involved in forming multivesicular bodies and sorting endosomal cargo into them, and ESCRT-III is thought to mediate membrane fission, possibly with VPS4. It is found as a cytosolic monomer or as an oligomer on endosomal membranes.
CHMP2B has the aliases CHMP2.5, VPS2B and DKFZP564O123. HGNC lists its previous name as chromatin modifying protein 2B. The protein belongs to the SNF7 family and to the HGNC charged multivesicular body proteins and ESCRT-III gene groups.
Yes. According to NCBI Gene, mutations in the CHMP2B gene result in one form of familial frontotemporal lobar degeneration. The protein is expressed in neurons of all major brain regions. A mouse ortholog, Chmp2b, exists; check the datasheet of any product for its validated reactivity.
Other ESCRT-III components, VPS4 ATPases and endosomal sorting proteins that may be of interest alongside CHMP2B.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UQN3; product specifications from Assay Genie datasheets.