CNTN4
CNTN4 (contactin 4, also known as BIG-2) is a glycosylphosphatidylinositol-anchored neuronal membrane protein of the contactin family. It mediates cell surface interactions during nervous system development and may contribute to the formation of axon connections. Browse Assay Genie's current range of CNTN4 research reagents below, or read on for the biology behind the target.
CNTN4 is a member of the contactin family, a group of axon-associated cell adhesion molecules that mediate cell surface interactions during nervous system development. Contactins function in neuronal network formation and plasticity. The CNTN4 protein has some neurite outgrowth-promoting activity and may be involved in synaptogenesis. It is described as a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system.
The human CNTN4 gene encodes a protein that belongs to the immunoglobulin superfamily and is classed by HGNC within the I-set domain containing group and the contactins. UniProt lists its subcellular location as the cell membrane and as secreted. Alternative splicing of the CNTN4 gene results in multiple transcript variants. Orthologous genes are named Cntn4 in both mouse and rat, which allows the protein to be studied in common model systems.
Deletion or mutation of CNTN4 may play a role in 3p deletion syndrome and autism spectrum disorders, which makes it a gene of interest in neurodevelopmental research. The alias BIG-2 appears alongside the approved symbol in the literature. Other contactin family members, and the contactin-associated proteins (CNTNAP family), are often studied together with CNTN4 when researchers examine axonal connectivity and cell adhesion in the nervous system.
CNTN4 mediates cell surface interactions during nervous system development, making it relevant to studies of how neuronal networks are assembled.
CNTN4 has some neurite outgrowth-promoting activity and may play a role in the formation of axon connections in the developing nervous system.
Contactins function in neuronal network formation and plasticity, and CNTN4 may be involved in synaptogenesis.
Deletion or mutation of CNTN4 may play a role in 3p deletion syndrome and autism spectrum disorders.
CNTN4 is a contactin that mediates cell surface interactions during nervous system development. It has some neurite outgrowth-promoting activity and may be involved in synaptogenesis. As a GPI-anchored neuronal membrane protein, it may help form axon connections in the developing nervous system.
CNTN4 stands for contactin 4, and UniProt names the protein Contactin-4. BIG-2 is a recorded alias. Alternative splicing of the CNTN4 gene produces multiple transcript variants, and the protein is found at the cell membrane and in a secreted form.
Mouse and rat both carry an orthologous gene called Cntn4. In humans, deletion or mutation of CNTN4 may play a role in 3p deletion syndrome and autism spectrum disorders. Check the datasheet of any product for its validated reactivity.
Other contactins and contactin-associated proteins involved in neuronal adhesion and nervous system development.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8IWV2; product specifications from Assay Genie datasheets.