SOCS1
SOCS1 (suppressor of cytokine signalling 1, also known as SOCS-1, SSI-1, JAB, TIP3 and Cish1) is a cytokine-inducible negative regulator of cytokine signalling. It restrains the JAK/STAT pathway and is an essential brake on interferon signalling. Browse Assay Genie's current range of SOCS1 research reagents below, or read on for the biology behind the target.
SOCS1 is an essential negative regulator of type I and type II interferon (IFN) signalling, and of other cytokines including IL-2, IL-4, IL-6 and leukaemia inhibitory factor (LIF). It down-regulates cytokine signalling by inhibiting the JAK/STAT signalling pathway. It acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, it also suppresses Tec protein-tyrosine kinase activity. SOCS1 additionally regulates IFN-gamma-mediated sensory neuron survival.
The SOCS1 protein is a probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex. This complex mediates the ubiquitination and subsequent proteasomal degradation of target proteins. UniProt places the protein in the nucleus and in cytoplasmic vesicles. The SOCS1 gene is a member of the SOCS family and belongs to the SOCS1 family; HGNC classes it among SH2 domain containing proteins and the suppressors of cytokine signalling. Mouse and rat both carry a Socs1 ortholog.
Expression of the SOCS1 gene is induced by a subset of cytokines, including IL-2, IL-3, erythropoietin (EPO), CSF2/GM-CSF and IFN-gamma. The protein works downstream of cytokine receptors and takes part in a negative feedback loop that attenuates cytokine signalling. This is why the family was named STAT-induced STAT inhibitor (SSI), the origin of the alias SSI-1. Knockout studies in mice suggest SOCS1 modulates IFN-gamma action, which is required for normal postnatal growth and survival.
SOCS1 is an essential negative regulator of type I and type II interferon signalling, making it central to studies of interferon response control.
SOCS1 binds JAK proteins and IFNGR1 and inhibits their kinase activity, providing a model for feedback control of JAK/STAT signalling.
Cytokines such as IL-2, IL-3, EPO, GM-CSF and IFN-gamma induce SOCS1, which then attenuates cytokine signalling in a negative feedback loop.
SOCS1 is a probable substrate recognition component of an ECS E3 ubiquitin ligase complex that directs target proteins to proteasomal degradation.
SOCS1 is a negative regulator of type I and type II interferon signalling and of cytokines including IL-2, IL-4, IL-6 and LIF. It inhibits the JAK/STAT pathway by binding JAK proteins and IFNGR1 and blocking their kinase activity. It also probably acts in an ECS E3 ubiquitin ligase complex.
SOCS1 is also called SOCS-1, SSI-1, JAB, TIP3 and Cish1. SSI stands for STAT-induced STAT inhibitor, the name given to the family because its members are induced by cytokines and in turn inhibit STAT signalling. The HGNC full name is suppressor of cytokine signalling 1.
Mouse and rat each have a Socs1 ortholog. Knockout studies in mice suggested SOCS1 modulates IFN-gamma action, which is required for normal postnatal growth and survival. Check the datasheet of any product for its validated reactivity.
Other members of the SOCS family of cytokine-inducible negative regulators.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O15524; product specifications from Assay Genie datasheets.