GLP2R
GLP2R, the glucagon-like peptide 2 receptor, is a cell-surface G protein-coupled receptor that binds glucagon-like peptide 2 (GLP-2). It is closely related to the glucagon receptor and is linked to intestinal growth, mucosal repair and metabolic homeostasis. Browse Assay Genie's current range of GLP2R research reagents below, or read on for the biology behind the target.
GLP2R is the receptor for glucagon-like peptide 2 (GLP-2). Its activity is mediated by G proteins that activate adenylyl cyclase, so ligand binding at the cell surface is converted into an intracellular signal. The receptor is a member of the G protein-coupled receptor 2 family and sits in the glucagon receptor family, to which the glucagon receptor also belongs.
Activation of GLP2R stimulates intestinal growth. It increases villus height, enhances crypt cell proliferation and reduces enterocyte apoptosis, which promotes nutrient absorption and helps maintain gut barrier integrity. GLP2R signalling also regulates intestinal blood flow, supports mucosal healing after injury and modulates gut hormone secretion. It has additionally been implicated in metabolic homeostasis, and may influence energy balance and glucose metabolism.
Dysregulation of the receptor or its signalling pathways is associated with intestinal disorders, including short bowel syndrome and inflammatory bowel disease. For this reason GLP2R is regarded as a potential therapeutic target for enhancing intestinal regeneration and treating gastrointestinal disease. The GLP2R gene is also known by its previous name, glucagon-like peptide 2 receptor, and has orthologues named Glp2r in mouse and rat, which allows the pathway to be studied in rodent models.
GLP2R activation increases villus height and crypt cell proliferation while reducing enterocyte apoptosis, making it central to studies of gut growth and repair.
GLP2R signalling supports gut barrier integrity and mucosal healing after injury, and also regulates intestinal blood flow.
Dysregulated GLP2R signalling is associated with short bowel syndrome and inflammatory bowel disease, and the receptor is a potential therapeutic target.
GLP2R has been implicated in metabolic homeostasis and may influence energy balance and glucose metabolism, alongside its role in modulating gut hormone secretion.
GLP2R is the receptor for glucagon-like peptide 2. Through G proteins it activates adenylyl cyclase. Its signalling stimulates intestinal growth, supports nutrient absorption and gut barrier integrity, regulates intestinal blood flow, aids mucosal healing and modulates gut hormone secretion.
The HGNC name is glucagon like peptide 2 receptor, with the previous name glucagon-like peptide 2 receptor; no other aliases are listed. It belongs to the G protein-coupled receptor 2 family and the glucagon receptor family, and is closely related to the glucagon receptor.
Dysregulation of GLP2R signalling is associated with short bowel syndrome and inflammatory bowel disease, and the receptor is a potential therapeutic target for gastrointestinal disease. Mouse and rat both have an orthologous Glp2r gene; check the datasheet of any product for its validated reactivity.
Related glucagon-like peptide targets and other proteins involved in gut hormone signalling with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95838; product specifications from Assay Genie datasheets.