COQ10A
COQ10A (coenzyme Q10A, previously FLJ32452) is a mitochondrial coenzyme Q-binding protein of the COQ10 family. It is required for coenzyme Q function in the respiratory chain and may act as a chaperone for the quinone. Browse Assay Genie's current range of COQ10A research reagents below, or read on for the biology behind the target.
COQ10A is required for the function of coenzyme Q in the respiratory chain. UniProt annotation indicates that it may serve as a chaperone, or may be involved in transporting Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. In line with this, the NCBI Gene summary describes the protein as predicted to enable ubiquinone binding activity and to be involved in cellular respiration.
The COQ10A protein is annotated as a mitochondrial protein, and UniProt places it in the mitochondrial inner membrane, the compartment where the respiratory complexes operate. It belongs to the COQ10 family, which also includes COQ10B. The UniProt entry names it coenzyme Q-binding protein COQ10 homolog A, mitochondrial.
The COQ10A gene was named as a homolog of the yeast coenzyme Q10 gene, and earlier HGNC names, coenzyme Q10 homolog A (yeast) and coenzyme Q10 homolog A (S. cerevisiae), reflect this origin. FLJ32452 is a previous symbol. Because the available annotation is largely based on predictions and on the role of the family, COQ10A is of interest to researchers studying how coenzyme Q is handled within mitochondria. It is also relevant alongside other coenzyme Q-related proteins such as COQ9.
COQ10A is required for coenzyme Q function in the respiratory chain, making it relevant to studies of cellular respiration.
The protein may act as a chaperone or transporter of Q6 from its site of synthesis to the respiratory complexes.
COQ10A is predicted to enable ubiquinone binding, so it is a candidate for work on how quinones are bound and delivered.
Its localisation to the mitochondrial inner membrane supports studies of protein organisation where respiratory complexes function.
COQ10A is required for the function of coenzyme Q in the respiratory chain. UniProt notes it may serve as a chaperone or be involved in transporting Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.
The HGNC name is coenzyme Q10A, and the UniProt name is coenzyme Q-binding protein COQ10 homolog A, mitochondrial. FLJ32452 is a previous symbol, and earlier names were coenzyme Q10 homolog A (yeast) and (S. cerevisiae).
COQ10A belongs to the COQ10 family, which also includes COQ10B. Its names refer to the yeast coenzyme Q10 gene it is homologous to. It is functionally connected to coenzyme Q biology in mitochondria, as is COQ9.
COQ10 family member COQ10B and COQ9, a protein connected to coenzyme Q biology in mitochondria.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96MF6; product specifications from Assay Genie datasheets.