ANXA2
ANXA2 (annexin A2) is a member of the annexin family of calcium-dependent phospholipid-binding proteins, which contribute to the regulation of cellular growth and signal transduction. It is also known as LIP2, ANX2, ANX2L4, CAL1H and LPC2D. Browse Assay Genie's current range of ANXA2 research reagents below, or read on for the biology behind the target.
ANXA2 belongs to the annexin family, a group of calcium-dependent phospholipid-binding proteins that play a role in the regulation of cellular growth and in signal transduction pathways. According to the NCBI Gene summary, annexin A2 functions as an autocrine factor that heightens osteoclast formation and bone resorption. UniProt also records that it binds the CARDS toxin of Mycoplasma pneumoniae and probably serves as one receptor for this pathogen: when ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization, a symptom of infection, is seen.
The human ANXA2 gene is classified by HGNC in the Annexins gene group. UniProt lists the annexin A2 protein as secreted, with localisation to the extracellular space, extracellular matrix and basement membrane, as well as to the melanosome. The gene has three pseudogenes, located on chromosomes 4, 9 and 10, and multiple alternatively spliced transcript variants encoding different isoforms have been described. Mouse and rat both carry an orthologous Anxa2 gene.
Annexin A2 expression has been found to correlate with resistance to treatment in various forms of cancer, which makes the ANXA2 gene a recurring subject in oncology studies. Aliases found in the literature include LIP2, ANX2, ANX2L4, CAL1H and LPC2D. Researchers studying annexin A2 often compare it with other annexin family members, since they share the calcium-dependent phospholipid-binding property.
ANXA2 expression has been found to correlate with resistance to treatment in various cancer forms, making it a subject of oncology research.
Annexin A2 acts as an autocrine factor that heightens osteoclast formation and bone resorption, relevant to studies of bone remodelling.
ANXA2 binds M. pneumoniae CARDS toxin and probably serves as a receptor, supporting work on toxin binding and vacuolization.
As an annexin family member, ANXA2 is involved in the regulation of cellular growth and in signal transduction pathways.
ANXA2 is a calcium-dependent phospholipid-binding protein of the annexin family that plays a role in regulating cellular growth and signal transduction. It acts as an autocrine factor that heightens osteoclast formation and bone resorption, and it probably serves as a receptor for M. pneumoniae CARDS toxin.
ANXA2 (annexin A2) is also known as LIP2, ANX2, ANX2L4, CAL1H and LPC2D. Multiple alternatively spliced transcript variants encoding different isoforms have been found for the gene, and three pseudogenes are located on chromosomes 4, 9 and 10.
Mouse and rat each have an orthologous Anxa2 gene, so the protein can be studied in common model species; check the datasheet of any product for its validated reactivity. Annexin A2 expression has been found to correlate with resistance to treatment against various cancer forms.
Other annexin family members and calcium-dependent phospholipid-binding proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P07355; product specifications from Assay Genie datasheets.