LCP1
LCP1 (lymphocyte cytosolic protein 1), also known as plastin-2, L-plastin, PLS2, CP64 and LC64P, is an actin-binding protein of the plastin family. It contributes to T-cell activation and is expressed in haemopoietic cell lineages. Browse Assay Genie's current range of LCP1 research reagents below, or read on for the biology behind the target.
LCP1 is an actin-binding protein. It plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28, and it modulates the cell surface expression of IL2RA/CD25 and CD69. In the cell it is found in the cytoplasm and cytoskeleton, and it is also annotated at cell junctions and in cell projections, including the ruffle membrane.
The LCP1 gene encodes plastin-2, the L isoform of the plastins. Plastins are a family of actin-binding proteins conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous isoforms (L and T) have been identified, and plastin 1, also called fimbrin, is a third isoform expressed at high levels in the small intestine. HGNC places LCP1 in the plastin family and among EF-hand domain containing proteins.
The L isoform is expressed only in haemopoietic cell lineages, whereas the T isoform is found in other normal cells of solid tissues that have replicative potential, such as fibroblasts, endothelial cells, epithelial cells and melanocytes. L-plastin has nonetheless been found in many types of malignant human cells of non-haemopoietic origin, which suggests that its expression is induced alongside tumorigenesis in solid tissues. The name reflects this history: the previous HGNC name was lymphocyte cytosolic protein 1 (L-plastin). Researchers studying LCP1 may work with an LCP1 antibody, LCP1 ELISA kit or recombinant LCP1 protein to examine its expression and function.
LCP1 plays a role in T-cell activation following costimulation through TCR/CD3 and CD2 or CD28.
As an actin-binding plastin, LCP1 is a tool for studying cytoskeletal organisation, cell junctions and ruffle membrane projections.
L-plastin expression is restricted to haemopoietic lineages among normal cells, making LCP1 a useful marker of this compartment.
L-plastin is found in many malignant cells of non-haemopoietic origin, suggesting induced expression during tumorigenesis.
LCP1 is an actin-binding protein. It plays a role in T-cell activation in response to costimulation through TCR/CD3 and CD2 or CD28, and it modulates the cell surface expression of IL2RA/CD25 and CD69.
LCP1 is also called plastin-2, L-plastin, PLS2, CP64 and LC64P. Its previous HGNC name was lymphocyte cytosolic protein 1 (L-plastin). The L refers to the isoform expressed in haemopoietic lineages, as distinct from the T isoform and plastin 1 (fimbrin).
Among normal cells, the L isoform is expressed only in haemopoietic lineages. However, L-plastin has been found in many malignant human cells of non-haemopoietic origin, suggesting induced expression in tumorigenesis. The mouse ortholog is Lcp1; check the datasheet of any product for its validated reactivity.
Related lymphocyte cytosolic proteins and T-cell signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P13796; product specifications from Assay Genie datasheets.