PTMA
PTMA (prothymosin alpha, also known as TMSA) is a small nuclear protein of the pro/parathymosin family. It binds histones, calcium ions and transcription factors, and has been linked to immune function and the negative regulation of apoptosis. Browse Assay Genie's current range of PTMA research reagents below, or read on for the biology behind the target.
Prothymosin alpha is a member of the pro/parathymosin family. UniProt annotates it as a protein that may mediate immune function by conferring resistance to certain opportunistic infections. The NCBI Gene summary adds a molecular picture: the PTMA protein enables DNA-binding transcription factor binding, calcium ion binding and histone binding, and it is involved in the negative regulation of the apoptotic process.
UniProt lists the protein's subcellular location as the nucleus, and the NCBI Gene summary places it in the cytosol and nucleoplasm. Its histone-binding and transcription factor-binding activities fit with a role in nuclear processes, although the sources supplied here do not define a detailed mechanism. Researchers studying chromatin biology, cell survival or immune function may therefore find the PTMA protein a useful subject of investigation.
The human PTMA gene is catalogued by HGNC as prothymosin alpha, with TMSA as an alias. Earlier names include prothymosin, alpha (gene sequence 28) and prothymosin, alpha. HGNC places the gene in the group of microRNA protein coding host genes. Orthologous genes named Ptma are recorded in both mouse and rat, which allows the gene to be studied in common rodent models.
PTMA is involved in the negative regulation of the apoptotic process, making it relevant to studies of how cells resist programmed cell death.
The protein enables histone binding and is found in the nucleus, which makes it a candidate for studies of nuclear and chromatin-associated function.
PTMA enables DNA-binding transcription factor binding activity, so it is relevant to research on how transcription factors are modulated.
UniProt notes that prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
PTMA, or prothymosin alpha, enables transcription factor binding, calcium ion binding and histone binding, and is involved in negative regulation of apoptosis. UniProt also notes that it may mediate immune function by conferring resistance to certain opportunistic infections.
HGNC lists the approved name as prothymosin alpha and gives TMSA as an alias. Previous names are prothymosin, alpha (gene sequence 28) and prothymosin, alpha. UniProt uses the protein name Prothymosin alpha, and the entry belongs to the pro/parathymosin family.
Yes. Orthologous genes named Ptma are recorded in both mouse and rat, so the gene can be studied in these rodent models. As always, check the datasheet of any product for its validated reactivity.
Other nuclear proteins, apoptosis regulators and histone-binding targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P06454; product specifications from Assay Genie datasheets.