CTSV
CTSV (cathepsin V) is a lysosomal cysteine protease of the peptidase C1 family, also known as cathepsin L2, CTSL2 or CTSU. It may have an important role in corneal physiology and has been linked to tumour processes through its expression in some carcinomas. Browse Assay Genie's current range of CTSV research reagents below, or read on for the biology behind the target.
CTSV is a cysteine protease. It belongs to the peptidase C1 family and is a lysosomal cysteine proteinase, so it acts within the lysosome. The UniProt annotation states that it may have an important role in corneal physiology, and the NCBI Gene summary repeats this. Beyond this, the available annotation does not define its substrates or mechanism in more detail.
The human CTSV gene encodes a single protein, cathepsin L2 in UniProt nomenclature. HGNC classifies it in the cathepsins, elastases and cysteine endopeptidases gene groups, and assigns the enzyme number EC 3.4.22.43. NCBI Gene reports that alternatively spliced variants have been identified and that these encode the same protein, so the splice variation does not change the protein sequence.
The gene has previously been named CTSL2 and CTSU, and the protein was formerly called cathepsin L2. These names still appear in older literature, so it helps to search under all of them. NCBI Gene reports that the gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland or peritumoral tissues. This suggests a possible role in tumour processes. For this reason CTSV is of interest to researchers studying lysosomal proteases in cancer biology as well as in the cornea.
CTSV may have an important role in corneal physiology, making it a candidate protease for studies of corneal tissue biology.
CTSV is expressed in colorectal and breast carcinomas but not in the normal tissues examined, suggesting a possible role in tumour processes.
As a lysosomal cysteine proteinase of the peptidase C1 family, CTSV is relevant to studies of lysosomal proteolysis and cathepsin biology.
CTSV is grouped with the cathepsins, elastases and cysteine endopeptidases, so it is often examined alongside related cathepsins such as the one it was once named after.
CTSV is a lysosomal cysteine protease of the peptidase C1 family. UniProt and NCBI Gene both note that it may have an important role in corneal physiology. Its expression in colorectal and breast carcinomas also suggests a possible role in tumour processes.
CTSV stands for cathepsin V. HGNC lists the aliases and previous symbols CTSU and CTSL2, and the previous name cathepsin L2. UniProt uses Cathepsin L2 as the protein name. Alternatively spliced variants of the gene encode the same protein.
NCBI Gene reports that CTSV is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland or peritumoral tissues. This suggests a possible role in tumour processes, though the source text does not establish a specific mechanism. Check the datasheet of any product for its validated reactivity.
Other cathepsins and lysosomal proteases that are often studied alongside CTSV.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O60911; product specifications from Assay Genie datasheets.