MUC13
MUC13 (mucin 13, cell surface associated; also known as DRCC1) is an epithelial and haemopoietic transmembrane mucin that may play a role in cell signalling. It belongs to the family of secreted and cell surface glycoproteins expressed by ductal and glandular epithelial tissues. Browse Assay Genie's current range of MUC13 research reagents below, or read on for the biology behind the target.
MUC13 is a transmembrane mucin found in epithelial and haemopoietic cells. UniProt annotates it as a protein that may play a role in cell signalling. Its subcellular locations are given as the cell membrane, including the apical cell membrane, and as a secreted form. This places MUC13 at the cell surface, where epithelial mucins interface with the external environment.
Epithelial mucins, such as MUC13, are a family of secreted and cell surface glycoproteins expressed by ductal and glandular epithelial tissues. The MUC13 gene encodes the protein Mucin-13, and HGNC classifies it within the mucins and the SEA domain containing gene groups. Researchers studying the MUC13 protein often do so in the context of epithelial biology and the wider mucin family, which includes other membrane-bound and secreted members.
The gene has had several names. HGNC lists the alias DRCC1, from its earlier name down-regulated in colon cancer 1, and a previous name, mucin 13, epithelial transmembrane. The current approved name is mucin 13, cell surface associated. Orthologues are annotated in mouse and rat, both named Muc13, which allows comparative work across these species. Anyone searching for a MUC13 antibody, a MUC13 ELISA kit or other MUC13 reagents should note these older names in the literature.
MUC13 is a cell surface glycoprotein expressed by ductal and glandular epithelial tissues, making it a relevant member of the epithelial mucin family.
UniProt notes that MUC13 may play a role in cell signalling, which motivates work on how transmembrane mucins relay signals at the cell surface.
MUC13 is annotated at the apical cell membrane and as a secreted form, so it is useful for studying polarised epithelial surfaces.
UniProt describes MUC13 as both an epithelial and haemopoietic transmembrane mucin, supporting investigation beyond classical epithelia.
MUC13 is an epithelial and haemopoietic transmembrane mucin that may play a role in cell signalling. It is annotated at the cell membrane, including the apical membrane, and also as a secreted form. Its precise functions are not fully defined in the source annotation.
MUC13 is also known as DRCC1, from its earlier name down-regulated in colon cancer 1. A previous HGNC name was mucin 13, epithelial transmembrane. The current approved name is mucin 13, cell surface associated, and the UniProt entry is named Mucin-13.
Mouse and rat both have a Muc13 orthologue, allowing comparative studies of this epithelial mucin. MUC13 belongs to the mucin and SEA domain containing gene groups. Check the datasheet of any product for its validated reactivity.
Other membrane-bound and secreted mucins that belong to the same wider family of epithelial glycoproteins.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H3R2; product specifications from Assay Genie datasheets.