SERPINB6
SERPINB6 (serpin family B member 6, also known as PTI, CAP, PI6 and DFNB91) is a cytoplasmic member of the ovalbumin-type serpin subfamily. It inhibits serine proteinases including cathepsin G, kallikrein-8 and thrombin, and is linked to hearing function in the inner ear. Browse Assay Genie's current range of SERPINB6 research reagents below, or read on for the biology behind the target.
SERPINB6 is a serine proteinase inhibitor. Annotation describes it as an inhibitor of cathepsin G, kallikrein-8 and thrombin, and it may be involved in regulating serine proteinases present in the brain or extravasated from the blood. In the inner ear it may protect cells against leakage of lysosomal content during stress; loss of this protection is thought to result in cell death and sensorineural hearing loss. Researchers studying this protein often look at the SERPINB6 protein in the context of proteinase control and cellular stress protection.
The SERPINB6 gene encodes a member of the serpin superfamily and, more specifically, the ovalbumin (ov)-serpin subfamily, a grouping that also includes SERPINB2, SERPINB5, SERPINB9, SERPINB12 and SERPINB13 among the clade B serpins. The protein is found in the cytoplasm. Alternatively spliced transcript variants have been reported for the gene. The mouse homologue, Serpinb6, was found to be expressed in the hair cells of the inner ear, which supports the use of mouse models for hearing research.
The protein was originally discovered as a placental thrombin inhibitor, which is reflected in the alias PTI. Its other names include CAP and PI6, and the previous gene name was serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6. The DFNB91 alias comes from the association of mutations in this gene with nonsyndromic progressive hearing loss, formerly listed as deafness, autosomal recessive 91. That link makes SERPINB6 relevant to work on inherited deafness as well as on serpin biology.
Mutations in SERPINB6 are associated with nonsyndromic progressive hearing loss, and the mouse homologue is expressed in inner ear hair cells.
SERPINB6 inhibits cathepsin G, kallikrein-8 and thrombin, making it a subject for studies of serpin-proteinase interactions.
The protein may protect against leakage of lysosomal content during stress, and its loss leads to cell death in the inner ear.
SERPINB6 may regulate serine proteinases in the brain or those that have extravasated from the blood.
SERPINB6 is a serine proteinase inhibitor that acts against cathepsin G, kallikrein-8 and thrombin. It may help regulate proteinases in the brain or those leaking from the blood, and it may protect inner ear cells from lysosomal leakage during stress.
SERPINB6 is also called PTI, CAP, PI6 and DFNB91, and is named Serpin B6 by UniProt. Earlier names include serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6. NCBI notes that alternatively spliced transcript variants exist.
Mutations in the SERPINB6 gene are associated with nonsyndromic progressive hearing loss (DFNB91). A mouse homologue, Serpinb6, is expressed in inner ear hair cells. Check the datasheet of any product for its validated reactivity.
Other clade B ov-serpins and serine proteinase inhibitors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P35237; product specifications from Assay Genie datasheets.