CD300LB
CD300LB (CD300 molecule like family member b, also known as TREM5 and CLM7) is a cell-membrane receptor of the immunoglobulin superfamily expressed on myeloid cells. It acts as an activating immune receptor through the adapter TYROBP and through GRB2 recruitment. Browse Assay Genie's current range of CD300LB research reagents below, or read on for the biology behind the target.
CD300LB is an activating immune receptor. It signals through its interaction with TYROBP, an adapter that carries an ITAM (immunoreceptor tyrosine-based activation motif). It can also signal independently of TYROBP, by recruiting the adapter protein GRB2. This dual route places the CD300LB protein among the nonclassical activating receptors, which sit at the cell surface and pass signals into the cell.
NCBI Gene describes CD300LB as a nonclassical activating receptor of the immunoglobulin (Ig) superfamily that is expressed on myeloid cells. UniProt lists the protein as CMRF35-like molecule 7 and places it at the cell membrane. It belongs to the CD300 family, and HGNC classifies the CD300LB gene within the V-set domain containing group together with the CD300 molecule family. Mouse has an ortholog named Cd300lb, which is relevant when planning comparative work.
The gene has gone by several names. Aliases and previous symbols include TREM5 and CLM7, and earlier HGNC names were CD300 antigen like family member B and CD300 molecule-like family member b. Researchers searching the literature for CD300LB should check these older names. Studies of CD300LB generally address activating receptor signalling in myeloid cells, and how adapter usage through TYROBP and GRB2 shapes the response of those cells.
CD300LB is expressed on myeloid cells, making it a relevant marker and receptor for studying how these cells sense and respond to their environment.
CD300LB signals as an activating immune receptor, providing a model for how Ig superfamily receptors trigger cellular responses.
CD300LB interacts with the ITAM-bearing adapter TYROBP, so it is useful for studying adapter-dependent receptor activation.
CD300LB can act independently of TYROBP by recruiting GRB2, offering a route to study adapter-independent activation.
CD300LB acts as an activating immune receptor. It signals through its interaction with the ITAM-bearing adapter TYROBP, and also independently by recruiting GRB2. NCBI Gene describes it as a nonclassical activating Ig superfamily receptor expressed on myeloid cells.
CD300LB is also known as TREM5 and CLM7, and UniProt names the protein CMRF35-like molecule 7. Earlier HGNC names were CD300 antigen like family member B and CD300 molecule-like family member b. Use all of these when searching the literature.
Yes, the mouse ortholog is Cd300lb. CD300LB belongs to the CD300 family and to the V-set domain containing gene group. For any product, check the datasheet for its validated reactivity before planning cross-species work.
Other CD300 family members, signalling adapters and myeloid cell markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt A8K4G0; product specifications from Assay Genie datasheets.