MSRA
MSRA (methionine sulfoxide reductase A) is an enzyme that reduces methionine sulfoxide in proteins back to methionine, repairing oxidative damage. It is also known by its UniProt name, mitochondrial peptide methionine sulfoxide reductase. Browse Assay Genie's current range of MSRA research reagents below, or read on for the biology behind the target.
MSRA catalyses the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. This makes it a repair enzyme for proteins that have been inactivated by oxidation: by restoring oxidised methionine residues, it allows the affected protein to recover its biological activity. UniProt notes a particular role in repairing oxidised methionine residues in key lens proteins, such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS), thereby restoring their function and maintaining lens transparency.
The MSRA gene encodes a ubiquitous and highly conserved protein. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. According to UniProt, the protein is found in the mitochondrion, including the mitochondrial matrix, as well as in the cytoplasm, nucleus and membrane fractions. Alternative splicing of the MSRA gene results in multiple transcript variants. Orthologues are annotated in both mouse and rat (Msra), which supports its use in comparative studies.
MSRA belongs to the MsrA methionine sulfoxide reductase family and is classified by HGNC in the methionine sulfoxide reductases gene group. Its enzyme activity is assigned EC 1.8.4.11. Because it acts on oxidatively damaged proteins, MSRA is a natural focus for work on oxidative stress, protein repair and tissue-specific protection against oxidative damage.
MSRA reduces methionine sulfoxide back to methionine, making it central to studies of how cells reverse oxidative damage to proteins.
The enzyme restores biological activity to oxidatively damaged proteins, providing a model for studying repair rather than degradation of modified proteins.
MSRA repairs oxidised alpha-crystallin and cytochrome c, a function linked to maintaining lens transparency.
Expression is highest in kidney and nervous tissue, making MSRA relevant to research on oxidative protection in these tissues.
MSRA catalyses the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. It acts as a repair enzyme for proteins inactivated by oxidation, including alpha-crystallin and cytochrome c in the lens, helping to restore their function and maintain lens transparency.
HGNC names the gene methionine sulfoxide reductase A, and UniProt lists the protein as mitochondrial peptide methionine sulfoxide reductase. No alternative gene symbols are recorded. NCBI Gene reports that alternative splicing produces multiple transcript variants of the MSRA gene.
Yes. NCBI describes the MSRA protein as ubiquitous and highly conserved, and mouse and rat orthologues (both Msra) are annotated. Human and animal studies show the highest expression in kidney and nervous tissue. Check the datasheet of any product for its validated reactivity.
Other methionine sulfoxide reductases and MSRA substrate proteins, including lens crystallins and cytochrome c, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UJ68; product specifications from Assay Genie datasheets.