RAB41
RAB41 (Ras-related protein Rab-41) is a small GTPase of the Rab family that regulates intracellular membrane trafficking. It is required for normal Golgi ribbon organisation and for transport from the endoplasmic reticulum to the Golgi. Browse Assay Genie's current range of RAB41 research reagents below, or read on for the biology behind the target.
RAB41 belongs to the Rab family of the small GTPase superfamily. Rab proteins are key regulators of intracellular membrane trafficking, acting from the formation of transport vesicles through to their fusion with target membranes. Like other Rabs, RAB41 cycles between an inactive GDP-bound form and an active GTP-bound form. The active form recruits distinct sets of downstream effectors to membranes, and these effectors are directly responsible for vesicle formation, movement, tethering and fusion. RAB41 is required for normal Golgi ribbon organisation and for ER-to-Golgi trafficking.
The RAB41 gene encodes a small GTP-binding protein of the largest family within the Ras superfamily. Its cycling between GDP-bound and GTP-bound states is controlled by GTP hydrolysis-activating proteins (GAPs), and RAB41 can be activated by the GAP protein RN-Tre. The protein is localised to the Golgi complex, and UniProt annotates it as cytoplasmic. As a GTPase, it is assigned EC 3.6.5.2.
HGNC classifies the gene in the group of RAB, member RAS oncogene GTPases, under the name RAB41, member RAS oncogene family; its previous name was RAB41, member RAS homolog family. Researchers studying secretory pathway organisation, Golgi structure and Rab GTPase regulation use the RAB41 protein and gene as tools to examine how individual Rabs contribute to membrane transport.
RAB41 is required for normal Golgi ribbon organisation, making it relevant to studies of Golgi structure and maintenance.
RAB41 is needed for ER-to-Golgi trafficking, so it is a useful target for dissecting early secretory pathway transport.
RAB41 switches between GDP- and GTP-bound states and can be activated by the GAP RN-Tre, supporting work on GTPase regulation.
Rabs recruit effectors that drive vesicle formation, movement, tethering and fusion, and RAB41 contributes to this general membrane trafficking machinery.
RAB41 is a small GTPase that regulates membrane trafficking. In its active GTP-bound form it recruits effectors to membranes that mediate vesicle formation, movement, tethering and fusion. It is required for normal Golgi ribbon organisation and for ER-to-Golgi trafficking.
The official name is RAB41, member RAS oncogene family, previously RAB41, member RAS homolog family; UniProt lists it as Ras-related protein Rab-41. No other aliases are recorded. HGNC places it in the RAB, member RAS oncogene GTPases group, and it belongs to the Rab family of the small GTPase superfamily.
Like other Rabs, RAB41 cycles between an inactive GDP-bound state and an active GTP-bound state, a cycle controlled by GTP hydrolysis-activating proteins (GAPs). According to the NCBI Gene summary, RAB41 can be activated by the GAP protein RN-Tre, and it localises to the Golgi complex.
Other Rab family GTPases and membrane trafficking regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q5JT25; product specifications from Assay Genie datasheets.