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CSGALNACT2
CSGALNACT2, or chondroitin sulfate N-acetylgalactosaminyltransferase 2, is a Golgi-resident glycosyltransferase that takes part in chondroitin sulfate synthesis. It is also known as GALNACT2, GALNACT-2, MGC40204 and PRO0082. Browse Assay Genie's current range of CSGALNACT2 research reagents below, or read on for the biology behind the target.
CSGALNACT2 catalyses the transfer of 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). According to UniProt, the enzyme is required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. The NCBI Gene summary likewise describes the encoded protein as involved in elongation during chondroitin sulfate synthesis.
The enzyme is classed as EC 2.4.1.174 and belongs to the chondroitin N-acetylgalactosaminyltransferase family. HGNC places the gene in the beta 4-glycosyltransferases group. The protein is located in the Golgi apparatus, in the membrane of the Golgi stack, where glycosaminoglycan chain assembly takes place. Researchers studying the CSGALNACT2 gene or the CSGALNACT2 protein typically do so in the context of proteoglycan glycosylation.
Alternative splicing of the gene results in multiple transcript variants, and two related pseudogenes have been identified on chromosome X. The mouse ortholog is Csgalnact2. Older names and aliases found in the literature include GALNACT2, GALNACT-2, MGC40204 and PRO0082, so searches for CSGALNACT2 antibody or CSGALNACT2 ELISA kit reagents may also need to take these into account.
CSGALNACT2 is involved in elongation during chondroitin sulfate synthesis, making it a relevant enzyme for studying how chondroitin chains are built.
The enzyme transfers GalNAc from UDP-GalNAc to glucuronic acid, providing a defined activity for substrate and mechanism studies (EC 2.4.1.174).
As a Golgi stack membrane protein, CSGALNACT2 is a candidate for work on the organisation of glycan assembly in the Golgi apparatus.
UniProt reports a requirement for CSGALNACT2 in adding the first GalNAc to the core tetrasaccharide linker, relevant to chain initiation studies.
CSGALNACT2 transfers 1,4-N-acetylgalactosamine from UDP-GalNAc to the non-reducing end of glucuronic acid. It is required for adding the first GalNAc to the core tetrasaccharide linker and for elongating chondroitin chains, so it contributes to chondroitin sulfate synthesis.
The HGNC name is chondroitin sulfate N-acetylgalactosaminyltransferase 2. Aliases are GALNACT2, GALNACT-2, MGC40204 and PRO0082. Alternative splicing of the gene produces multiple transcript variants, so literature and databases may refer to the protein under several of these labels.
A mouse ortholog, Csgalnact2, is recorded for the human gene. Two related pseudogenes are also reported on chromosome X. For work in other species, check the datasheet of any product for its validated reactivity.
Other chondroitin sulfate biosynthesis enzymes and glycosaminoglycan pathway proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8N6G5; product specifications from Assay Genie datasheets.
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