MIP-1 delta
MIP-1 delta, encoded by the CCL15 gene, is a secreted CC chemokine that attracts T cells and monocytes. It is also known as HCC-2, NCC-3, MIP-5, Lkn-1, MIP-1d and HMRP-2B, and signals mainly through the receptor CCR1. Browse Assay Genie's current range of MIP-1 delta research reagents below, or read on for the biology behind the target.
MIP-1 delta (C-C motif chemokine 15) is a chemotactic factor that attracts T cells and monocytes. It does not attract neutrophils, eosinophils or B cells, which makes its target cell profile relatively selective. It acts mainly through the CC chemokine receptor CCR1 and also binds CCR3. Researchers studying leukocyte recruitment often use the MIP-1 delta protein to probe CCR1-dependent migration.
The protein is secreted and belongs to the intercrine beta (chemokine CC) family. CC chemokines are characterised by two adjacent cysteines. The CCL15 gene sits within a cluster of similar CC chemokine genes on chromosome 17. The proprotein is processed into several smaller functional peptides. Truncated forms such as CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the longer form, so the processing state of the protein matters when interpreting activity in an assay.
The gene has gone by many names, including small inducible cytokine subfamily A (Cys-Cys), member 15 (SCYA15, SCYL3), and the HGNC name C-C motif chemokine ligand 15. Other aliases include HCC-2, NCC-3, MIP-5, Lkn-1, MIP-1d and HMRP-2B. NCBI also reports naturally occurring readthrough transcripts that run from the CCL15 gene into the downstream gene CCL14. This is worth remembering when designing MIP-1 delta detection strategies, such as an antibody or ELISA kit, or when interpreting transcript data.
MIP-1 delta signals mainly through CCR1 and also binds CCR3, making it a useful ligand for studying CC chemokine receptor pathways.
The chemokine attracts T cells and monocytes but not neutrophils, eosinophils or B cells, supporting studies of selective leukocyte recruitment.
The proprotein is cleaved into smaller peptides, and truncated forms are more potent chemoattractants than the longer form.
CCL15 lies in a chromosome 17 cluster of CC chemokine genes and produces readthrough transcripts into CCL14, relevant to gene regulation research.
MIP-1 delta is a secreted chemotactic factor that attracts T cells and monocytes, but not neutrophils, eosinophils or B cells. It acts mainly through the CC chemokine receptor CCR1 and also binds CCR3. Truncated forms are more potent chemoattractants than the longer form.
The HGNC symbol is CCL15, for C-C motif chemokine ligand 15. Aliases include HCC-2, NCC-3, SCYL3, MIP-5, Lkn-1, MIP-1d, HMRP-2B and SCYA15. Older names include small inducible cytokine subfamily A (Cys-Cys), member 15. Check which name a source uses when searching the literature.
MIP-1 delta belongs to the intercrine beta (chemokine CC) family, whose members are secreted proteins with two adjacent cysteines. Its gene lies in a cluster of similar genes on chromosome 17. Check the datasheet of any product for its validated reactivity.
Other CC chemokine ligands that sit alongside MIP-1 delta in chemokine signalling research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q16663; product specifications from Assay Genie datasheets.