F5
F5 (coagulation factor V, fV) is a secreted plasma glycoprotein and a central regulator of haemostasis. It acts as an essential cofactor in the blood coagulation cascade, supporting the conversion of prothrombin to thrombin by factor Xa. Browse Assay Genie's current range of F5 research reagents below, or read on for the biology behind the target.
F5 is a critical cofactor for the prothrombinase activity of activated factor X (factor Xa), which activates prothrombin to thrombin. Factor V circulates in plasma as an inactive precursor. During coagulation, thrombin releases the activation peptide, which generates a heavy chain and a light chain held together by calcium ions. This activated form participates with activated coagulation factor X to drive thrombin generation, which makes the F5 protein a central regulator of haemostasis.
The F5 gene encodes coagulation factor V, a secreted protein that belongs to the multicopper oxidase family. HGNC places it in the multicopper oxidase family and in the coagulation factors gene group. A mouse ortholog, also named F5, is recorded for the gene, which is relevant when choosing models for coagulation studies.
The protein was formerly listed as coagulation factor V (proaccelerin, labile factor), and fV remains a common abbreviation. Defects in the gene result in one of two clinical outcomes. One is an autosomal recessive haemorrhagic diathesis. The other is an autosomal dominant form of thrombophilia known as activated protein C resistance. Factor V is therefore studied in both bleeding and thrombotic contexts, and it is a frequent subject for work that uses an F5 antibody or an F5 ELISA kit to examine the protein in biological samples.
F5 is an essential cofactor of the cascade, supporting factor Xa in the activation of prothrombin to thrombin.
As a central regulator of haemostasis, factor V is a key protein for studying how clotting is controlled.
Defects in F5 can cause an autosomal dominant thrombophilia known as activated protein C resistance.
Loss-of-function defects in F5 result in an autosomal recessive haemorrhagic diathesis, making it relevant to bleeding disorder studies.
F5 encodes coagulation factor V, a critical cofactor for the prothrombinase activity of factor Xa. This activity converts prothrombin to thrombin. Factor V circulates in plasma and is activated when thrombin releases its activation peptide, leaving a heavy chain and a light chain joined by calcium ions.
F5 is the HGNC symbol for coagulation factor V, abbreviated fV. The earlier name was coagulation factor V (proaccelerin, labile factor). These names refer to the same gene and plasma protein, so all of them are useful when searching the literature.
Defects in F5 cause either an autosomal recessive haemorrhagic diathesis or an autosomal dominant thrombophilia called activated protein C resistance. A mouse ortholog, also named F5, exists. Check the datasheet of any product for its validated reactivity.
Other coagulation factors and cascade partners that sit alongside F5 in haemostasis research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P12259; product specifications from Assay Genie datasheets.