GTPBP4
GTPBP4 (GTP binding protein 4, also known as CRFG, NGB and NOG1) is a nucleolar GTPase involved in the biogenesis of the 60S ribosomal subunit. It also acts as a repressor of TP53, preventing TP53 stabilisation and cell cycle arrest. Browse Assay Genie's current range of GTPBP4 research reagents below, or read on for the biology behind the target.
GTPBP4 is a GTP-binding protein that participates in the biogenesis of the 60S ribosomal subunit, the large subunit of the ribosome. A second annotated role is as a TP53 repressor: GTPBP4 prevents TP53 stabilisation and the cell cycle arrest that follows. These two activities link ribosome assembly to control of the TP53 pathway, which makes the GTPBP4 protein a useful subject for work on nucleolar function and cell proliferation.
GTP-binding proteins are GTPases that act as molecular switches. They are active when GTP is bound and inactive when GDP is bound, and the switch is turned off when the protein hydrolyses its own bound GTP to GDP. GTPBP4 belongs to the TRAFAC class OBG-HflX-like GTPase superfamily, in the OBG GTPase family and the NOG subfamily. It localises to the nucleus, specifically the nucleolus, the site of ribosome subunit assembly. The human protein is encoded by the GTPBP4 gene, and orthologous genes named Gtpbp4 are present in mouse and rat.
The protein is known by several aliases, including CRFG, NGB and NOG1, as well as the older clone-derived designations FLJ10690 and FLJ10686. The NOG1 name reflects its place in the NOG subfamily of OBG GTPases. Researchers studying GTPBP4 typically work on ribosome biogenesis, nucleolar stress and the regulation of TP53, and need reliable tools to detect the protein and measure its levels in experimental systems.
GTPBP4 is involved in the biogenesis of the 60S ribosomal subunit, making it a target for studies of large subunit assembly.
GTPBP4 acts as a TP53 repressor, preventing TP53 stabilisation and cell cycle arrest, which is relevant to p53 signalling research.
The protein is found in the nucleolus, so it is relevant to research on nucleolar organisation and function.
As an OBG-family GTPase of the NOG subfamily, GTPBP4 is studied as a GTP/GDP-regulated molecular switch.
GTPBP4 is involved in the biogenesis of the 60S ribosomal subunit. It also acts as a TP53 repressor, preventing TP53 stabilisation and cell cycle arrest. The protein is located in the nucleolus, where ribosomal subunits are assembled.
GTPBP4 (GTP binding protein 4) is also called CRFG, NGB and NOG1. Older designations include FLJ10690 and FLJ10686. UniProt lists the protein name as GTP-binding protein 4. Check the datasheet of any product for its validated reactivity.
Yes. Mouse and rat both have an ortholog named Gtpbp4. The protein belongs to the OBG GTPase family, NOG subfamily, within the TRAFAC class OBG-HflX-like GTPase superfamily. Check the datasheet of any product for its validated reactivity.
Pathway partners and related proteins in ribosome biogenesis and TP53 signalling with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BZE4; product specifications from Assay Genie datasheets.