ELAVL1
ELAVL1, also known as HuR, Hua and MelG, is an RNA-binding protein of the ELAV family that binds the 3'-UTR of target mRNAs and increases their stability. It is a widely studied regulator of post-transcriptional gene expression. Browse Assay Genie's current range of ELAVL1 research reagents below, or read on for the biology behind the target.
ELAVL1 (ELAV-like protein 1) binds to the 3'-UTR of mRNAs and increases their stability. It recognises poly-U elements and AU-rich elements (AREs), and binds avidly to the AU-rich element in FOS and interleukin-3 mRNAs. For the FOS element it binds a core region of 27 nucleotides containing AUUUA, AUUUUA and AUUUUUA motifs, and in vitro it prefers the 5'-UUUU[AG]UUU-3' motif. It also stabilises leptin mRNA, which carries an ARE in its 3' UTR.
The protein contributes to several regulatory processes. In embryonic stem cell differentiation, it preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A) and stabilises them, promoting differentiation. It can also bind m6A-containing mRNAs, and contributes to MYC stability through m6A-containing MYC mRNA. Together with ZNF385A, it binds the 3'-UTR of p53/TP53 mRNA to control nuclear export induced by CDKN2A, so it may regulate p53/TP53 expression and mediate part of the CDKN2A anti-proliferative activity. It may also bind CCNB1 mRNA with ZNF385A. In cells it is found in the cytoplasm and nucleus, including stress granules and P-bodies.
The ELAVL1 gene encodes a member of the ELAVL family of RNA-binding proteins, which contain several RNA recognition motifs and belong to the RRM elav family. Because AREs can signal mRNA degradation, binding by ELAVL proteins stabilises ARE-containing transcripts. The previous name was ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R). The gene has been implicated in many biological processes and in several diseases, including cancer. It is highly expressed in many cancers and may be useful in cancer diagnosis, prognosis and therapy. Mouse and rat orthologs are both named Elavl1.
ELAVL1 binds AU-rich elements in 3'-UTRs and stabilises target mRNAs, making it a central subject for studying mRNA turnover.
ELAVL1 is highly expressed in many cancers and may be useful in cancer diagnosis, prognosis and therapy.
ELAVL1 stabilises mRNAs not methylated by m6A to promote embryonic stem cell differentiation, and also contributes to MYC stability via m6A-containing MYC mRNA.
With ZNF385A, ELAVL1 binds p53/TP53 mRNA to control its CDKN2A-induced nuclear export, linking it to anti-proliferative signalling.
ELAVL1 is an RNA-binding protein that binds poly-U and AU-rich elements in the 3'-UTR of target mRNAs and increases their stability. Known targets include FOS, interleukin-3, leptin and MYC mRNAs. It also helps control nuclear export of p53/TP53 mRNA together with ZNF385A.
Yes. HuR is a widely used alias for ELAVL1, and other aliases include Hua and MelG. The earlier gene name was ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R). Searching for any of these names should lead to the same protein, so check the datasheet of any product for its validated reactivity.
NCBI Gene reports that ELAVL1 has been implicated in a variety of biological processes and linked to several diseases, including cancer. It is highly expressed in many cancers and could be useful for diagnosis, prognosis and therapy. Mouse and rat both have an ortholog called Elavl1.
Other ELAVL family RNA-binding proteins and the mRNA targets and regulators linked to ELAVL1 function.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15717; product specifications from Assay Genie datasheets.